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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gfi1btm2Tmo
targeted mutation 2, Tarik Moroy
MGI:4868580
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gfi1btm2Tmo/Gfi1btm2Tmo
Tg(Mx1-cre)1Cgn/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4868582
cn2
 		Gfi1tm1Wep/Gfi1tm1Wep
Gfi1btm2Tmo/Gfi1btm2Tmo
Tg(Mx1-cre)1Cgn/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4868585


Genotype
MGI:4868582
cn1
Allelic
Composition		 Gfi1btm2Tmo/Gfi1btm2Tmo
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1btm2Tmo mutation (0 available); any Gfi1b mutation (21 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:167416 )
N
• pIpC injection induces cre expression
decreased erythrocyte cell number ( J:167416 )
• in the peripheral blood
thrombocytopenia ( J:167416 )
• in peripheral blood
increased hematopoietic stem cell number ( J:167416 )
• increased frequency of hematopoietic stem cells in bone marrow, spleen, and peripheral blood
increased splenocyte number ( J:167416 )
• due to the expansion of erythroid progenitors
abnormal hematopoietic stem cell physiology ( J:167416 )
• increased apoptosis but still below 2.5%
• increased levels of reactive oxygen species

immune system
increased splenocyte number ( J:167416 )
• due to the expansion of erythroid progenitors




Genotype
MGI:4868585
cn2
Allelic
Composition		 Gfi1tm1Wep/Gfi1tm1Wep
Gfi1btm2Tmo/Gfi1btm2Tmo
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1btm2Tmo mutation (0 available); any Gfi1b mutation (21 available)
Gfi1tm1Wep mutation (0 available); any Gfi1 mutation (31 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematopoietic stem cell number ( J:167416 )
• numbers drastically reduced 15 days after the first pIpC injection to induce cre expression
• numbers restored by 40 days
• Gfi1b excision is incomplete




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory