mortality/aging
• 50% mortality before 32 weeks of age
• mortality increases to 80% by 3-5 weeks if Lyz2tm1(cre)Ifo is homozygous
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growth/size/body
• 50% reduction in body size
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• splenomegaly with loss of lymphoid follicles
• normal cell number but composition includes more large immature and myeloid cells and fewer lymphocytes
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hematopoietic system
• increased number of neutrophiles
• decrease in thymocytes
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• loss of a distinct medulla and cortex
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• reduced bone marrow erythropoiesis
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• splenic extramedullary myelopoiesis
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• expanded number of neutrophiles
• reduced erythropoiesis
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• thrombocytosis
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• decreased percentage but not in absolute numbers in peripheral blood
• absolute number of B cells reduced in the spleen
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• decreased percentage but not in absolute numbers in peripheral blood
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• decreased percentage in peripheral blood
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• slightly increased in absolute numbers in peripheral blood
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• reduced numbers in the peritoneal cavity
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• 5 fold increase in leukocytes in peripheral blood
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• increased more than 10 fold
• accumulate in the lung alveolar spaces and around the large blood vessels
• accumulate in the small intestine, particularly the jejunum
• increased numbers in the peritoneal cavity
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• increased more than 10 fold
• increase of the inflammatory subclass
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• disrupted architecture
• granulocyte infiltration
• infiltration of neutrophiles
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• splenomegaly with loss of lymphoid follicles
• normal cell number but composition includes more large immature and myeloid cells and fewer lymphocytes
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• reduction in macrophage number
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• loss of lymphoid follicles
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• reduction in macrophage number
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immune system
• decrease in thymocytes
• increased number of neutrophiles
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• loss of a distinct medulla and cortex
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• splenic extramedullary myelopoiesis
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• decreased percentage but not in absolute numbers in peripheral blood
• absolute number of B cells reduced in the spleen
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• decreased percentage but not in absolute numbers in peripheral blood
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• decreased percentage in peripheral blood
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• slightly increased in absolute numbers in peripheral blood
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• reduced numbers in the peritoneal cavity
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• 5 fold increase in leukocytes in peripheral blood
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• increased more than 10 fold
• accumulate in the lung alveolar spaces and around the large blood vessels
• accumulate in the small intestine, particularly the jejunum
• increased numbers in the peritoneal cavity
|
• increased more than 10 fold
• increase of the inflammatory subclass
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• disrupted architecture
• granulocyte infiltration
• infiltration of neutrophiles
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• splenomegaly with loss of lymphoid follicles
• normal cell number but composition includes more large immature and myeloid cells and fewer lymphocytes
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• reduction in macrophage number
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• loss of lymphoid follicles
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• reduction in macrophage number
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• loss of lymphoid follicles
• infiltration of neutrophiles
• 4fewer macrophage
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endocrine/exocrine glands
• increased number of neutrophiles
• decrease in thymocytes
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• loss of a distinct medulla and cortex
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