Phenotypes associated with this allele

• Allele Symbol: Cflar^tm1.2Pope
• Allele Name: targeted mutation 1.2, Richard M Pope
• Allele ID: MGI:4868693
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cflar^tm1.1Pope/Cflar^tm1.2Pope Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd	MGI:4868712

Genotype
MGI:4868712

cn1

• Allelic Composition: Cflar^tm1.1Pope/Cflar^tm1.2Pope; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:167430 )

• 50% mortality before 32 weeks of age

• mortality increases to 80% by 3-5 weeks if Lyz2^tm1(cre)Ifo is homozygous

growth/size/body

decreased body size ( J:167430 )

• 50% reduction in body size

enlarged spleen ( J:167430 )

• splenomegaly with loss of lymphoid follicles

• normal cell number but composition includes more large immature and myeloid cells and fewer lymphocytes

hematopoietic system

abnormal thymus morphology ( J:167430 )

• increased number of neutrophiles

• decrease in thymocytes

abnormal thymus corticomedullary boundary morphology ( J:167430 )

• loss of a distinct medulla and cortex

abnormal definitive hematopoiesis ( J:167430 )

abnormal erythropoiesis ( J:167430 )

• reduced bone marrow erythropoiesis

abnormal myelopoiesis ( J:167430 )

• splenic extramedullary myelopoiesis

anemia ( J:167430 )

abnormal bone marrow cell number ( J:167430 )

• expanded number of neutrophiles

• reduced erythropoiesis

thrombocytosis ( J:167430 )

• thrombocytosis

abnormal lymphocyte cell number ( J:167430 )

abnormal B cell number ( J:167430 )

• decreased percentage but not in absolute numbers in peripheral blood

• absolute number of B cells reduced in the spleen

abnormal CD4-positive, alpha-beta T cell number ( J:167430 )

• decreased percentage but not in absolute numbers in peripheral blood

abnormal CD8-positive, alpha-beta T cell number ( J:167430 )

• decreased percentage in peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:167430 )

• slightly increased in absolute numbers in peripheral blood

decreased macrophage cell number ( J:167430 )

• reduced numbers in the peritoneal cavity

increased leukocyte cell number ( J:167430 )

• 5 fold increase in leukocytes in peripheral blood

increased granulocyte number ( J:167430 )

increased eosinophil cell number ( J:167430 )

increased neutrophil cell number ( J:167430 )

• increased more than 10 fold

• accumulate in the lung alveolar spaces and around the large blood vessels

• accumulate in the small intestine, particularly the jejunum

• increased numbers in the peritoneal cavity

increased monocyte cell number ( J:167430 )

• increased more than 10 fold

• increase of the inflammatory subclass

abnormal spleen morphology ( J:167430 )

• disrupted architecture

• granulocyte infiltration

• infiltration of neutrophiles

enlarged spleen ( J:167430 )

• splenomegaly with loss of lymphoid follicles

• normal cell number but composition includes more large immature and myeloid cells and fewer lymphocytes

abnormal spleen red pulp morphology ( J:167430 )

• reduction in macrophage number

abnormal spleen B cell follicle morphology ( J:167430 )

• loss of lymphoid follicles

abnormal spleen marginal zone morphology ( J:167430 )

• reduction in macrophage number

immune system

abnormal thymus morphology ( J:167430 )

• increased number of neutrophiles

• decrease in thymocytes

abnormal thymus corticomedullary boundary morphology ( J:167430 )

• loss of a distinct medulla and cortex

abnormal myelopoiesis ( J:167430 )

• splenic extramedullary myelopoiesis

abnormal lymphocyte cell number ( J:167430 )

abnormal B cell number ( J:167430 )

• decreased percentage but not in absolute numbers in peripheral blood

• absolute number of B cells reduced in the spleen

abnormal CD4-positive, alpha-beta T cell number ( J:167430 )

• decreased percentage but not in absolute numbers in peripheral blood

abnormal CD8-positive, alpha-beta T cell number ( J:167430 )

• decreased percentage in peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:167430 )

• slightly increased in absolute numbers in peripheral blood

decreased macrophage cell number ( J:167430 )

• reduced numbers in the peritoneal cavity

increased leukocyte cell number ( J:167430 )

• 5 fold increase in leukocytes in peripheral blood

increased granulocyte number ( J:167430 )

increased eosinophil cell number ( J:167430 )

increased neutrophil cell number ( J:167430 )

• increased more than 10 fold

• accumulate in the lung alveolar spaces and around the large blood vessels

• accumulate in the small intestine, particularly the jejunum

• increased numbers in the peritoneal cavity

increased monocyte cell number ( J:167430 )

• increased more than 10 fold

• increase of the inflammatory subclass

abnormal spleen morphology ( J:167430 )

• disrupted architecture

• granulocyte infiltration

• infiltration of neutrophiles

enlarged spleen ( J:167430 )

• splenomegaly with loss of lymphoid follicles

• normal cell number but composition includes more large immature and myeloid cells and fewer lymphocytes

abnormal spleen red pulp morphology ( J:167430 )

• reduction in macrophage number

abnormal spleen B cell follicle morphology ( J:167430 )

• loss of lymphoid follicles

abnormal spleen marginal zone morphology ( J:167430 )

• reduction in macrophage number

abnormal abdominal lymph node morphology ( J:167430 )

• loss of lymphoid follicles

• infiltration of neutrophiles

• 4fewer macrophage

endocrine/exocrine glands

abnormal thymus morphology ( J:167430 )

• increased number of neutrophiles

• decrease in thymocytes

abnormal thymus corticomedullary boundary morphology ( J:167430 )

• loss of a distinct medulla and cortex