Analysis Tools
homeostasis/metabolism
|
• mice exhibit reduced exercise capacity compared with wild-type mice
|
|
• when fed a high-fat diet
|
|
• when fed a high-fat diet
|
|
• before exercise and after exercise
|
|
• before exercise
|
|
• mice exhibit increased susceptibility to diet-induced skeletal muscle insulin resistance compared with similarly treated wild-type mice
|
|
• mice fed a high-fat diet and stimulated with insulin exhibit an increase in ceramides in the tibialis anterior compared with similarly treated wild-type mice
|
|
• aminoimidazole carboxamide ribonucleotide (AICAR)-treated skeletal muscles fail to exhibit an increased in glucose uptake and exhibit a blunted reduction in blood glucose level unlike similarly treated wild-type muscle
• however, AICAR-induced fatty acid oxidation is normal
|
muscle
|
• aminoimidazole carboxamide ribonucleotide (AICAR)-treated skeletal muscles fail to exhibit an increased in glucose uptake unlike similarly treated wild-type muscle
|
|
• mice fed a high-fat diet exhibit increased glucose uptake compared with similarly treated wild-type mice
|
|
• before exercise
|
|
• mice exhibit reduced muscle force compared with wild-type mice
|
growth/size/body
|
• when fed a high-fat diet
|
liver/biliary system
|
• before exercise and after exercise
|
behavior/neurological
|
• mice exhibit reduced exercise capacity compared with wild-type mice
|
cellular
|
• aminoimidazole carboxamide ribonucleotide (AICAR)-treated skeletal muscles fail to exhibit an increased in glucose uptake unlike similarly treated wild-type muscle
|
|
• mice fed a high-fat diet exhibit increased glucose uptake compared with similarly treated wild-type mice
|
