Phenotypes associated with this allele

• Allele Symbol: Atmin^tm1Axbe
• Allele Name: targeted mutation 1, Axel Behrens
• Allele ID: MGI:4868760
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atmin^tm1Axbe/Atmin^tm1Axbe Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:4868763

Genotype
MGI:4868763

cn1

• Allelic Composition: Atmin^tm1Axbe/Atmin^tm1Axbe; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased body size and reduced dopaminergic neurons in Atmin^tm1Axbe/Atmin^tm1Axbe Tg(Nes-cre)1Kln/0 mice

mortality/aging

premature death ( J:167331 )

• after 1 year of age

nervous system

astrocytosis ( J:167331 )

loss of dopaminergic neurons ( J:167331 )

decreased neuron number ( J:167331 )

• in aging mice

neurodegeneration ( J:167331 )

• associated with increased DNA damage

behavior/neurological

increased anxiety-related response ( J:167331 )

• in a light/dark test

hyperactivity ( J:167331 )

growth/size/body

decreased body weight ( J:167331 )

• from the first week after birth and onward