Phenotypes associated with this allele

• Allele Symbol: App^tm2.1Ldad
• Allele Name: targeted mutation 2.1, Luciano D'Adamio
• Allele ID: MGI:4868765
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm2.1Ldad/App^tm2.1Ldad	involves: 129 * C57BL/6J	MGI:4868768

Genotype
MGI:4868768

hm1

• Allelic Composition: App^tm2.1Ldad/App^tm2.1Ldad
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

myositis ( J:166989 )

• mice exhibit small clusters of swollen muscle fibers with increased cytoplasmic eosinophilia and occasional karyorrhexis unlike in wild-type mice

increased variability of skeletal muscle fiber size ( J:166989 )

centrally nucleated skeletal muscle fibers ( J:166989 )

muscle degeneration ( J:166989 )

• mice exhibit multifocal myofiber degeneration in the appendicular musculature unlike wild-type mice

nervous system

nervous system phenotype ( J:166989 )

N • mice exhibit normal brain organization

immune system

myositis ( J:166989 )

• mice exhibit small clusters of swollen muscle fibers with increased cytoplasmic eosinophilia and occasional karyorrhexis unlike in wild-type mice