Analysis Tools
mortality/aging
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• median survival of fourth generation mice is 43.5 weeks compared with 86.8 weeks for wild-type mice
• however, treatment with tamoxifen lengthens survival
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reproductive system
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• however, treatment with tamoxifen reduces testes germ cell apoptosis
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small testis
(
J:167227
)
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• in fourth generation mice
• however, tamoxifen-treatment normalizes testis size
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• fourth generation male mice produce smaller litters than wild-type mice
• however, tamoxifen-treatment normalizes litter size
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nervous system
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• neurospheres from fourth generation mice are rare and smaller in diameters compared with wild-type cells
• fourth generation mice exhibit decreased proliferation of cells in the subventricular zone (SVZ) compared with wild-type mice
• however, tamoxifen-treatment partially restores neurosphere morphology and numbers and proliferation within the SVZ
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• neural stem cell cultures from fourth generation mice exhibit decreased self-renewal activity compared with wild-type cells
• however, tamoxifen-treatment partially restores self-renewal capacity
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• in fourth generation mice
• however, tamoxifen-treated mice exhibit improved brain weight
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• white matter of the corpus callosum in fourth generation mice exhibit fewer mature oligodendrocytes than in wild-type mice
• however, tamoxifen-treated mice normalizes oligodendrocyte numbers
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• white matter of the corpus callosum in fourth generation mice exhibit fewer mature oligodendrocytes than in wild-type mice
• however, tamoxifen-treated mice normalizes oligodendrocyte numbers
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• fourth generation mice exhibit thinner myelin sheathing compared with wild-type mice
• however, tamoxifen-treated mice reverses hypomyelination
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cellular
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• splenocytes from fourth generation mice exhibit Robertsonian fusions unlike wild-type cells
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• splenocytes from fourth generation mice exhibit short and dysfunctional telomeres compared with wild-type cells
• however, treatment of fibroblasts with tamoxifen lengthens telomeres
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|
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• however, treatment with tamoxifen reduces testes germ cell apoptosis
|
|
• neurospheres from fourth generation mice are rare and smaller in diameters compared with wild-type cells
• fourth generation mice exhibit decreased proliferation of cells in the subventricular zone (SVZ) compared with wild-type mice
• however, tamoxifen-treatment partially restores neurosphere morphology and numbers and proliferation within the SVZ
|
|
• neural stem cell cultures from fourth generation mice exhibit decreased self-renewal activity compared with wild-type cells
• however, tamoxifen-treatment partially restores self-renewal capacity
|
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• of fibroblasts from fourth generation mice
• however, treatment with tamoxifen reverses early senescence
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taste/olfaction
| N |
• fourth generation mice exhibit grossly normal olfactory epithelium
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• fourth generation mice fail to exhibit aversion to 2-methylbuteric acid compared with wild-type mice
• however, tamoxifen-treated mice exhibit improved olfaction
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immune system
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• fourth generation mice exhibit decreased spleen weight compared with wild-type mice
• however, treatment with tamoxifen normalizes spleen weight
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• with DNA damage
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digestive/alimentary system
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• fourth generation mice exhibit intestinal crypt cell atrophy compared with wild-type mice
• however, treatment with tamoxifen reverses intestinal crypt cell atrophy
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endocrine/exocrine glands
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• fourth generation mice exhibit intestinal crypt cell atrophy compared with wild-type mice
• however, treatment with tamoxifen reverses intestinal crypt cell atrophy
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small testis
(
J:167227
)
|
|
• in fourth generation mice
• however, tamoxifen-treatment normalizes testis size
|
hematopoietic system
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• fourth generation mice exhibit decreased spleen weight compared with wild-type mice
• however, treatment with tamoxifen normalizes spleen weight
|
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• with DNA damage
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