All Phenotypes Kiss1<tm1.1(cre)Uboe> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:5052335
cn2	Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Nhlh2^tm2Thbr/Nhlh2^tm2Thbr	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * C57BL/6J	MGI:5524042
cn3	Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5052334
cn4	Esr1^tm1.2Awo/Esr1^tm1.2Awo Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:4878879

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Kiss1^{tm1.1(cre)Uboe} mutation (0 available); any Kiss1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:173936 )

N	• mice are viable

reproductive system

reproductive system phenotype ( J:173936 )

N	• female mice exhibit normal onset of puberty, ovalutory cyclicity, and fertile

decreased ovary weight ( J:173936 )

• at P20

abnormal vagina development ( J:173936 )

• female mice exhibit slightly prolonged phases of cornification compared with wild-type mice

growth/size/body

increased body weight ( J:173936 )

• slightly increased in female mice between P31 and P46

endocrine/exocrine glands

decreased ovary weight ( J:173936 )

• at P20

Allelic Composition	Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Nhlh2^tm2Thbr/Nhlh2^tm2Thbr
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1^{tm1.1(cre)Uboe} mutation (0 available); any Kiss1 mutation (22 available)
Nhlh2^tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:199640 )

N	• mice exhibit normal uteri weight

growth/size/body

growth/size/body region phenotype ( J:199640 )

N	• mice exhibit normal weight

adipose tissue

adipose tissue phenotype ( J:199640 )

N	• mice exhibit normal visceral fat depots

Allelic Composition	Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(HBEGF)Awai} mutation (4 available); any Gt(ROSA)26Sor mutation (994 available)
Kiss1^{tm1.1(cre)Uboe} mutation (0 available); any Kiss1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal estrous cycle ( J:173936 )

• in diphtheria-treated mice

prolonged diestrus ( J:173936 )

• in diphtheria-treated mice

prolonged estrus ( J:173936 )

• in diphtheria-treated mice

female infertility ( J:173936 )

• in diphtheria-treated mice

nervous system

decreased neuron number ( J:173936 )

• diphtheria-treated mice exhibit ablation of Kiss1+ neurons

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:167285 )

N	• testis weight in adult males is not different from wild-type

absent corpus luteum ( J:167285 )

• in P35 ovaries, corpora lutea are completely absent

• in adult ovaries, few or no corpora lutea are observed

ovary cyst ( J:167285 )

• ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

• adult ovaries also show numerous large follicular cysts

early vaginal opening ( J:167285 )

• observed significantly earlier than in wild-type (13 vs 29 days postnatal)

abnormal estrous cycle ( J:167285 )

• females exhibit prolonged period (weeks or months) of persistent vaginal cornification

• in some animals, isolated "breakthrough" cycles occur followed by more periods of prolonged acyclicity

prolonged diestrus ( J:167285 )

• prolonged period of persistent vaginal cornification is followed by persistent diestrus state

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:167285 )

N	• serum luteinizing hormone (LH) levels in adult castrated (cx) males is not different from cx wil-type males; at P35 serum LH levels are similar in mutant and wild-type males

decreased circulating luteinizing hormone level ( J:167285 )

• in absence of ovarian restraint (after ovariectomy), LH secretion is greatly reduced in adult females compared to ovariectomized wild-type females

increased circulating luteinizing hormone level ( J:167285 )

• serum LH concentration is 6-7-fold higher at P15 than in age-matched wild-type; levels remain elevated at P25, then decline to wild-type levels by P35

endocrine/exocrine glands

absent corpus luteum ( J:167285 )

• in P35 ovaries, corpora lutea are completely absent

• in adult ovaries, few or no corpora lutea are observed

ovary cyst ( J:167285 )

• ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

• adult ovaries also show numerous large follicular cysts

growth/size/body

ovary cyst ( J:167285 )

• ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

• adult ovaries also show numerous large follicular cysts

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