About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cngb1tm1.1Glf
targeted mutation 1.1, Gordon L Fain
MGI:4878880
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cngb1tm1.1Glf/Cngb1tm1.1Glf involves: 129/Sv * C57BL/6 MGI:4881533
cx2
 		Cngb1tm1.1Glf/Cngb1tm1.1Glf
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc 		involves: 129/Sv * 129S1/Sv * C57BL/6 MGI:4881534
cx3
 		Cngb1tm1.1Glf/Cngb1tm1.1Glf
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc 		involves: 129/Sv * 129S1/Sv * C57BL/6 MGI:4881535


Genotype
MGI:4881533
hm1
Allelic
Composition		 Cngb1tm1.1Glf/Cngb1tm1.1Glf
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cngb1tm1.1Glf mutation (0 available); any Cngb1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:166744 )
N
• no defects in retina morphology are detected
abnormal rod electrophysiology ( J:166744 )
• the limiting time constant of the time the rods remain in saturation is reduced compared to wild-type rods




Genotype
MGI:4881534
cx2
Allelic
Composition		 Cngb1tm1.1Glf/Cngb1tm1.1Glf
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cngb1tm1.1Glf mutation (0 available); any Cngb1 mutation (61 available)
Guca1a/Guca1btm1Jnc mutation (0 available); any Guca1b mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal rod electrophysiology ( J:166744 )
• as in mice homozygous for Guca1a/Guca1btm1Jnc alone, flash sensitivity declines more rapidly as a function of background light intensity compared to wild-type mice
• when dark adapted rods are exposed to prolonged steps of light of varying duration the initial rapid decrease in circulating current seen in wild-type rods is absent but a slower current increase is seen and the turning off of light produces a transient overshoot
• the amplitudes of the slow recovery phase and of the overshoot are somewhat larger than in mice homozygous for Guca1a/Guca1btm1Jnc alone




Genotype
MGI:4881535
cx3
Allelic
Composition		 Cngb1tm1.1Glf/Cngb1tm1.1Glf
Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cngb1tm1.1Glf mutation (0 available); any Cngb1 mutation (61 available)
Guca1a/Guca1btm1Jnc mutation (0 available); any Guca1a mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal rod electrophysiology ( J:166744 )
• as in mice homozygous for Guca1a/Guca1btm1Jnc alone, flash sensitivity declines more rapidly as a function of background light intensity compared to wild-type mice
• when dark adapted rods are exposed to prolonged steps of light of varying duration the initial rapid decrease in circulating current seen in wild-type rods is absent but a slower current increase is seen and the turning off of light produces a transient overshoot
• the amplitudes of the slow recovery phase and of the overshoot are somewhat larger than in mice homozygous for Guca1a/Guca1btm1Jnc alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory