Phenotypes associated with this allele

• Allele Symbol: Adgrg6^tm1Apr
• Allele Name: targeted mutation 1, Andreas P Russ
• Allele ID: MGI:4878918
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgrg6^tm1Apr/Adgrg6^tm1Apr	either: 129S/SvEv-Gpr126^tm1Apr or B6.129S-Gpr126^tm1Apr or (involves: 129S/SvEv * MF1)	MGI:4878919

Genotype
MGI:4878919

hm1

• Allelic Composition: Adgrg6^tm1Apr/Adgrg6^tm1Apr
• Genetic Background: either: 129S/SvEv-Gpr126^tm1Apr or B6.129S-Gpr126^tm1Apr or (involves: 129S/SvEv * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Heart abnormalities in Adgrg6^tm1Apr/Adgrg6^tm1Apr mice

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:167309 )

• sharp loss in viability between E10.5 and E12.5 with no viable embryos found after E13.5

cardiovascular system

thin myocardium ( J:167309 )

• pronounced thinning is present after the onset of circulatory failure

dilated heart ventricle ( J:167309 )

abnormal blood circulation ( J:167309 )

• dead embryos show signs of circulatory failure (congestion, edema, internal hemorrhage)

internal hemorrhage ( J:167309 )

• seen in about 50% of embryos

homeostasis/metabolism

edema ( J:167309 )

muscle

thin myocardium ( J:167309 )

• pronounced thinning is present after the onset of circulatory failure