About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fli1tm1Morl
targeted mutation 1,Francois Morle
MGI:4878921
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fli1tm1Morl/Fli1tm1Morl
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * C57BL/6 * CBA MGI:4878939
cn2
 		Fli1tm1Morl/Fli1tm1.1Morl
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * C57BL/6 * CBA * DBA MGI:4878945


Genotype
MGI:4878939
cn1
Allelic
Composition		 Fli1tm1Morl/Fli1tm1Morl
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1Morl mutation (1 available); any Fli1 mutation (26 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:167426 )
N
• gene deletion frequency of 60-90% after pIpC injection
abnormal megakaryocyte differentiation ( J:167426 )
• marked decrease in the ratio of mature to immature megakaryocytes among bone marrow cells
• 10 fold decrease in CFU-MK in bone marrow
increased erythroid progenitor cell number ( J:167426 )
• BFU-E and CFU-E are increased
increased erythrocyte cell number ( J:167426 )
• increased erythrocytic cells
thrombocytopenia ( J:167426 )
• 33% decrease in the mean number of platelets in the circulation
• mild thrombocytopenia
decreased granulocyte number ( J:167426 )
• decreased granulocytes
• CFU-G are decreased
increased monocyte cell number ( J:167426 )
• CFU-M are increased

immune system
decreased granulocyte number ( J:167426 )
• decreased granulocytes
• CFU-G are decreased
increased monocyte cell number ( J:167426 )
• CFU-M are increased

cellular
abnormal megakaryocyte differentiation ( J:167426 )
• marked decrease in the ratio of mature to immature megakaryocytes among bone marrow cells
• 10 fold decrease in CFU-MK in bone marrow




Genotype
MGI:4878945
cn2
Allelic
Composition		 Fli1tm1Morl/Fli1tm1.1Morl
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1.1Morl mutation (1 available); any Fli1 mutation (26 available)
Fli1tm1Morl mutation (1 available); any Fli1 mutation (26 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:167426 )
N
• gene deletion frequency of 60-90% after pIpC injection
abnormal megakaryocyte differentiation ( J:167426 )
• marked decrease in the ratio of mature to immature megakaryocytes among bone marrow cells
• 10 fold decrease in CFU-MK in bone marrow
thrombocytopenia ( J:167426 )
• 33% decrease in the mean number of platelets in the circulation
• mild thrombocytopenia

cellular
abnormal megakaryocyte differentiation ( J:167426 )
• marked decrease in the ratio of mature to immature megakaryocytes among bone marrow cells
• 10 fold decrease in CFU-MK in bone marrow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory