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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fli1tm1.1Morl
targeted mutation 1.1, Francois Morle
MGI:4878922
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fli1tm1Morl/Fli1tm1.1Morl
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * C57BL/6 * CBA * DBA MGI:4878945


Genotype
MGI:4878945
cn1
Allelic
Composition		 Fli1tm1Morl/Fli1tm1.1Morl
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fli1tm1.1Morl mutation (1 available); any Fli1 mutation (26 available)
Fli1tm1Morl mutation (1 available); any Fli1 mutation (26 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:167426 )
N
• gene deletion frequency of 60-90% after pIpC injection
abnormal megakaryocyte differentiation ( J:167426 )
• marked decrease in the ratio of mature to immature megakaryocytes among bone marrow cells
• 10 fold decrease in CFU-MK in bone marrow
thrombocytopenia ( J:167426 )
• 33% decrease in the mean number of platelets in the circulation
• mild thrombocytopenia

cellular
abnormal megakaryocyte differentiation ( J:167426 )
• marked decrease in the ratio of mature to immature megakaryocytes among bone marrow cells
• 10 fold decrease in CFU-MK in bone marrow




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory