Analysis Tools
growth/size/body
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• detected in females by 4 weeks of age
• females are about 22% heavier than control littermates at 20 weeks of age
• males are about 11% heavier than control littermates at 20 weeks of age
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• increased weight gain on a high fat diet compared to diet matched controls
• increase in fat mass on a high fat diet is more pronounced in females
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behavior/neurological
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• increase in food intake on both standard and high fat diets
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adipose tissue
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• increase in fat mass in both males and females
• increase is greater than in heterozygous mice
• increase in fat mass on a high fat diet is more pronounced in females
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• increase in epigonadal and abdominal white adipose tissues
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homeostasis/metabolism
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• increased weight gain on a high fat diet compared to diet matched controls
• increase in fat mass on a high fat diet is more pronounced in females
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• in females at 20 weeks of age
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• in females at 20 weeks of age
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• in females at 20 weeks of age
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• in females at 20 weeks of age
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• on a standard diet during both the light and dark periods
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• in mice on a high fat diet relative to diet matched controls
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• increase in fasting insulin levels in males on a high fat diet at 16 weeks of age
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• in males and females at 8 weeks of age after a 16 h fast
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• in females on a high fat diet and in males on a standard diet
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