Phenotypes associated with this allele

• Allele Symbol: Slc17a6^tm1.1Thna
• Allele Name: targeted mutation 1.1, Thomas Hnasko
• Allele ID: MGI:4879093
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc17a6^tm1.1Thna/Slc17a6^tm1.1Thna Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^+ Slc6a3^tm1(cre)Xz/Slc6a3^+	involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:4879095
cn2	Mapt^tm2Arbr/Mapt^+ Shox2^tm1.1(cre)Oki/Shox2^+ Slc17a6^tm1.1Thna/Slc17a6^tm1.2Edw	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:5576701
cn3	Agrp^tm2(HBEGF)Rpa/Agrp^+ Slc17a6^tm1.1Thna/Slc17a6^tm1.1Thna	involves: 129S4/SvJaeSor * C57BL/6J	MGI:5427452

Genotype
MGI:4879095

cn1

• Allelic Composition: Slc17a6^tm1.1Thna/Slc17a6^tm1.1Thna; Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺; Slc6a3^tm1(cre)Xz/Slc6a3⁺
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dopaminergic neuron morphology ( J:167767 )

• only a minority of dopaminergic projections remain intake

abnormal excitatory postsynaptic currents ( J:167767 )

• YFP+ dopamine neurons fail to exhibit glutamatergic excitatory postsynaptic currents (EPSCs) unlike control cells

• at P9 to P10, mice exhibit a reduction in glutamatergic with fewer neurons responding to ventral tegmental area stimulation compared with similarly treated control cells

behavior/neurological

impaired behavioral response to cocaine ( J:167767 )

• cocaine-treated mice exhibit less locomotor activity compared with control mice

• however, cocaine-treated mice exhibit conditioned place preference

homeostasis/metabolism

decreased dopamine level ( J:167767 )

• the ventral striatum exhibit reduced dopamine and evoked dopamine release compared to in control mice

Genotype
MGI:5576701

cn2

• Allelic Composition: Mapt^tm2Arbr/Mapt⁺; Shox2^{tm1.1(cre)Oki}/Shox2⁺; Slc17a6^tm1.1Thna/Slc17a6^tm1.2Edw
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

nervous system

abnormal nervous system physiology ( J:209344 )

• frequencies of locomotor activity induced in isolated spinal cords increase with increasing NMDA concentrations, but are significantly lower than those observed in control spinal cords

• locomotor burst duration increases but duty cycle is not changed in mutant preparations (increased interburst interval)

• coefficients of variation of main locomotor parameters (cycle period, burst duration, amplitude, duty cycle) are increased compared to controls

• spinal cords from mutants display lower drug-evoked and stimulus-evoked locomotor frequencies

• flexor-extensor coupling is not significantly changed at any locomotor frequency

Genotype
MGI:5427452

cn3

• Allelic Composition: Agrp^{tm2(HBEGF)Rpa}/Agrp⁺; Slc17a6^tm1.1Thna/Slc17a6^tm1.1Thna
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

growth/size/body

abnormal postnatal growth/weight/body size ( J:182577 )

• diphtheria-treated mice injected with a virus expressing a AAV1-CreGFP into the nucleus tractus solitaries or parabrachial nucleus prevents starvation induced by AgRP neuron ablation unlike in control mice

increased body weight ( J:182577 )

• mice injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus without ablation of AgRP neurons

behavior/neurological

abnormal eating behavior ( J:182577 )

• mice injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus whether treated with diphtheria or not

• in diphtheria treated mice bilaterally with a virus expressing a AAV1-CreGFP into the nucleus tractus solitaries