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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Napbtm1Bros
targeted mutation 1, Nils Brose
MGI:4879973
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Napbtm1Bros/Napbtm1Bros Not Specified MGI:4880006
cx2
 		Napahyh/Napahyh
Napbtm1Bros/Napbtm1Bros 		involves: C57BL/10J MGI:4880007


Genotype
MGI:4880006
hm1
Allelic
Composition		 Napbtm1Bros/Napbtm1Bros
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Napbtm1Bros mutation (0 available); any Napb mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neuron physiology ( J:167753 )
• the total synaptic charge triggered by an action potential by total synaptic charge triggered by hypertonic sucrose solution is slightly increased compared to in control neurons

behavior/neurological




Genotype
MGI:4880007
cx2
Allelic
Composition		 Napahyh/Napahyh
Napbtm1Bros/Napbtm1Bros
Genetic
Background		 involves: C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Napahyh mutation (1 available); any Napa mutation (16 available)
Napbtm1Bros mutation (0 available); any Napb mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal synaptic vesicle number ( J:167753 )
• the pool of readily releasable vesicles is smaller than in control neurons
• stimulated total release and extrapolated pool of readily releasable vesicles is smaller than in control neurons
abnormal neuron physiology ( J:167753 )
• the slow release phase of synaptic vesicles is reduced compared to in wild-type neurons
• total charge transfer induced by calcimycin application is less than in similarly treated control neurons
abnormal excitatory postsynaptic currents ( J:167753 )
• following an action potential train, excitatory postsynaptic current depression is faster and stronger than in control neurons




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory