Phenotypes associated with this allele

• Allele Symbol: Crtc3^tm1Mmy
• Allele Name: targeted mutation 1, Marc R Montminy
• Allele ID: MGI:4879976
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crtc3^tm1Mmy/Crtc3^tm1Mmy	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4879977
ht2	Crtc3^tm1Mmy/Crtc3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4879978

Genotype
MGI:4879977

hm1

• Allelic Composition: Crtc3^tm1Mmy/Crtc3^tm1Mmy
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:167211 )

• 50% lower adipose tissue mass

abnormal brown fat cell morphology ( J:167211 )

decreased brown fat cell lipid droplet size ( J:167211 )

increased brown fat cell number ( J:167211 )

• about a 2 fold increase in the number of brown adipocytes in the intra-scapular fat pads

decreased white fat cell size ( J:167211 )

abnormal white adipose tissue physiology ( J:167211 )

• basal and isoproterenol induced lypolysis rates are increased

• cAMP levels are increased

homeostasis/metabolism

decreased circulating leptin level ( J:167211 )

• reduction in leptin levels is disproportionately low relative to the reduction in fat mass

decreased circulating free fatty acids level ( J:167211 )

increased body temperature ( J:167211 )

increased energy expenditure ( J:167211 )

• in mice on a high fat diet compared to wild-type littermates

decreased susceptibility to diet-induced obesity ( J:167211 )

• gain 35% less weight when placed on a high fat diet

• most of the difference in weight gain results from decreased fat accumulation

increased oxygen consumption ( J:167211 )

• in mice on a high fat diet compared to wild-type littermates

abnormal glucose homeostasis ( J:167211 )

decreased circulating insulin level ( J:167211 )

• in mice on a high fat diet compared to wild-type controls

increased insulin sensitivity ( J:167211 )

• on a normal chow diet

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:167211 )

• resistant to high fat diet induced hepatic steatosis

muscle

increased muscle cell glucose uptake ( J:167211 )

• glucose uptake into muscle is increased

cellular

abnormal cell physiology ( J:167211 )

• exposure to forskolin induces a greater accumulation of cAMP in MEFs and brown adipose tissue stromal-vascular cells

increased muscle cell glucose uptake ( J:167211 )

• glucose uptake into muscle is increased

growth/size/body

decreased susceptibility to diet-induced obesity ( J:167211 )

• gain 35% less weight when placed on a high fat diet

• most of the difference in weight gain results from decreased fat accumulation

Genotype
MGI:4879978

ht2

• Allelic Composition: Crtc3^tm1Mmy/Crtc3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

growth/size/body

decreased susceptibility to diet-induced obesity ( J:167211 )

• weight gain on a high fat diet is intermediate between wild-type and homozygous mutant mice

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:167211 )

• weight gain on a high fat diet is intermediate between wild-type and homozygous mutant mice