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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pax5tm3.1Mbu
targeted mutation 3.1, Meinrad Busslinger
MGI:4879988
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pax5tm3.1Mbu/Pax5tm3.1Mbu involves: 129P2/OlaHsd * C57BL/6 MGI:4879989


Genotype
MGI:4879989
hm1
Allelic
Composition		 Pax5tm3.1Mbu/Pax5tm3.1Mbu
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax5tm3.1Mbu mutation (0 available); any Pax5 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, complete penetrance ( J:75504 )
• death at weaning age, similar to other knockout mice of this gene

growth/size/body
postnatal growth retardation ( J:75504 )

immune system
arrested B cell differentiation ( J:75504 )
• B cell development is arrested at the pro-B stage

hematopoietic system
arrested B cell differentiation ( J:75504 )
• B cell development is arrested at the pro-B stage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory