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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pld2tm1.1Gdp
targeted mutation 1.1, Gilbert Di Paolo
MGI:4880012
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pld2tm1.1Gdp/Pld2tm1.1Gdp involves: 129/SvJ * C57BL/6 MGI:5468550
hm2
 		Pld2tm1.1Gdp/Pld2tm1.1Gdp involves: 129X1/SvJ * C57BL/6 MGI:4880013
cx3
 		Pld2tm1.1Gdp/Pld2tm1.1Gdp
Tg(APPSWE)2576Kha/0 		involves: 129X1/SvJ * C57BL/6 * SJL MGI:4880014
cx4
 		Pld2tm1.1Gdp/Pld2+
Tg(APPSWE)2576Kha/0 		involves: 129X1/SvJ * C57BL/6 * SJL MGI:4880015


Genotype
MGI:5468550
hm1
Allelic
Composition		 Pld2tm1.1Gdp/Pld2tm1.1Gdp
Genetic
Background		 involves: 129/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2tm1.1Gdp mutation (1 available); any Pld2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:193451 )
N
• implanted B16F10 mouse melanoma or mouse Lewis lung carcinoma cells exhibit normal growth, vascularization and metastasis




Genotype
MGI:4880013
hm2
Allelic
Composition		 Pld2tm1.1Gdp/Pld2tm1.1Gdp
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2tm1.1Gdp mutation (1 available); any Pld2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid level ( J:166741 )
• mice exhibit altered levels of specific phosphatidic acids compared to in wild-type mice
abnormal response/metabolism to endogenous compounds ( J:166741 )
• Abeta42 oligomers fail to suppress long term potential unlike in wild-type mice




Genotype
MGI:4880014
cx3
Allelic
Composition		 Pld2tm1.1Gdp/Pld2tm1.1Gdp
Tg(APPSWE)2576Kha/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2tm1.1Gdp mutation (1 available); any Pld2 mutation (49 available)
Tg(APPSWE)2576Kha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:166741 )
N
• mice exhibit normal spatial working memory unlike Tg(APPSWE)2576Kha mice
enhanced contextual conditioning behavior ( J:166741 )
• compared to Tg(APPSWE)2576Kha mice

homeostasis/metabolism
abnormal lipid level ( J:166741 )
• mice exhibit altered levels of specific phosphatidic acids compared to in wild-type mice

nervous system
abnormal synapse morphology ( J:166741 )
• mice exhibit synaptic protection compared to in Tg(APPSWE)2576Kha mice




Genotype
MGI:4880015
cx4
Allelic
Composition		 Pld2tm1.1Gdp/Pld2+
Tg(APPSWE)2576Kha/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2tm1.1Gdp mutation (1 available); any Pld2 mutation (49 available)
Tg(APPSWE)2576Kha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:166741 )
N
• mice exhibit normal spatial working memory unlike Tg(APPSWE)2576Kha mice
enhanced contextual conditioning behavior ( J:166741 )
• compared to Tg(APPSWE)2576Kha mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory