Phenotypes associated with this allele

• Allele Symbol: Dhrs3^{tm1(NCOM)Mfgc}
• Allele Name: targeted mutation 1, Mammalian Functional Genomics Centre
• Allele ID: MGI:4880251
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhrs3^tm1(NCOM)Mfgc/Dhrs3^tm1(NCOM)Mfgc	involves: C57BL/6 * C57BL/6N	MGI:5609152

Genotype
MGI:5609152

hm1

• Allelic Composition: Dhrs3^{tm1(NCOM)Mfgc}/Dhrs3^{tm1(NCOM)Mfgc}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: N01359P1_C_97W_B2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cleft palate, small eyes, and unfused eyelids in E18.5 Dhrs3^{tm1(NCOM)Mfgc}/Dhrs3^{tm1(NCOM)Mfgc} mice

mortality/aging

perinatal lethality, complete penetrance ( J:214109 )

• live born homozygotes are recovered at low frequency and die within 15 minutes of birth

• at E18.5, embryos are still alive and are recovered at close to expected frequencies

growth/size/body

cleft palate ( J:214109 )

• E18.5 mutants show cleft palate

homeostasis/metabolism

edema ( J:214109 )

• some E18.5 mutants show signs of edema

abnormal retinol level ( J:214109 )

• E13.5 embryos have about 4-fold reduced levels of retinol and retinyl esters but only slightly elevated levels of retinoic acid

abnormal enzyme/coenzyme activity ( J:214109 )

• retinaldehyde reductase and retinol dehydrogenase activities are decreased by about 4- and 2-fold, respectively, in embryos

abnormal retinol metabolism ( J:214109 )

• embryonic fibroblasts exhibit reduced metabolism of both retinaldehyde and retinol

vision/eye

microphthalmia ( J:214109 )

• small eyes at E18.5

eyelids open at birth ( J:214109 )

• unfused eyelids at E18.5

digestive/alimentary system

cleft palate ( J:214109 )

• E18.5 mutants show cleft palate

craniofacial

cleft palate ( J:214109 )

• E18.5 mutants show cleft palate