Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock4tm1(NCOM)Mfgc mutation
(0 available);
any
Dock4 mutation
(109 available)
|
|
|
mortality/aging
|
|
• no homozygotes are recovered at E7.5
|
Allelic
Composition |
Dock4tm1(NCOM)Mfgc/Dock4+
|
|
Genetic
Background |
involves: C57BL/6J * C57BL/6NCrl |
| Cell Lines |
N01793P1_C_109W_G2 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock4tm1(NCOM)Mfgc mutation
(0 available);
any
Dock4 mutation
(109 available)
|
|
|
Dock4tm1(NCOM)Mfgc/Dock4+ embryos show an increase in the frequency of blood vessels with small lumen width and a decrease in the frequency of large lumen width in the brain
cardiovascular system
|
|
• following implantation of a syngeneic breast cancer cell line (EO771) into the striatum of 9-10 week old heterozygotes, tumors show a reduction in blood vessel lumen width with 21% of vessels having lumens of larger caliber (>35 um) relative to ~38% in control tumors
|
|
|
• during developmental angiogenesis, E13.5 heterozygotes show only 9% of blood vessels with lumens of relatively large caliber (>20 um) in the brain parenchyma relative to ~31% in wild-type controls
• at E13.5, heterozygotes show a significant reduction in average blood vessel lumen width in the brain (15.1 um vs 18.6 um) relative to wild-type controls
• however, no differences in pericyte coverage of blood vessels are detected in the brain at E13.5
• no differences are detected in the lumen caliber of the aortas at E13.5
|
neoplasm
|
|
• following implantation of a syngeneic breast cancer cell line (EO771) into the striatum of 9-10 week old heterozygotes, tumors show a reduction in blood vessel lumen width with 21% of vessels having lumens of larger caliber (>35 um) relative to ~38% in control tumors
|
Analysis Tools