Phenotypes associated with this allele

• Allele Symbol: Prkag1^tm1.2Mfor
• Allele Name: targeted mutation 1.2, Marc Foretz
• Allele ID: MGI:4880680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkag1^tm1.2Mfor/Prkag1^tm1.2Mfor	involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * FVB/N	MGI:4880681

Genotype
MGI:4880681

hm1

• Allelic Composition: Prkag1^tm1.2Mfor/Prkag1^tm1.2Mfor
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:167779 )

• mice exhibit erythoblast hyperplasia in the bone marrow and spleens compared with wild-type mice

abnormal Kupffer cell morphology ( J:167779 )

• Kupffer cells accumulate iron deposits unlike in wild-type mice

enlarged spleen ( J:167779 )

• 3 times

extramedullary hematopoiesis ( J:167779 )

• in the spleen

anemia ( J:167779 )

hemolytic anemia ( J:167779 )

abnormal erythrocyte morphology ( J:167779 )

• erythrocytes exhibit rigid membranes and are less deformable compared with wild-type mice

• however, erythrocytes preserve a biconcave shape

decreased erythrocyte cell number ( J:167779 )

decreased hematocrit ( J:167779 )

decreased hemoglobin content ( J:167779 )

decreased mean corpuscular hemoglobin ( J:167779 )

decreased mean corpuscular hemoglobin concentration ( J:167779 )

decreased mean corpuscular volume ( J:167779 )

abnormal red blood cell deformability ( J:167779 )

• erythrocytes exhibit rigid membranes and are less deformable compared with wild-type mice

increased red blood cell distribution width ( J:167779 )

anisocytosis ( J:167779 )

macrocytosis ( J:167779 )

microcytosis ( J:167779 )

reticulocytosis ( J:167779 )

increased spleen iron level ( J:167779 )

• 7 times, predominantly in the red pulp

increased spleen red pulp amount ( J:167779 )

abnormal erythrocyte physiology ( J:167779 )

• erythrocyte survival is lower than in wild-type mice

increased erythrocyte clearance ( J:167779 )

homeostasis/metabolism

increased circulating bilirubin level ( J:167779 )

• 6 times

abnormal iron level ( J:167779 )

• mice exhibit increased iron deposits in the spleen, liver, and Kupffer cell compared with wild-type mice

increased spleen iron level ( J:167779 )

• 7 times, predominantly in the red pulp

increased liver iron level ( J:167779 )

• 2 times

cardiovascular system

abnormal Kupffer cell morphology ( J:167779 )

• Kupffer cells accumulate iron deposits unlike in wild-type mice

immune system

abnormal Kupffer cell morphology ( J:167779 )

• Kupffer cells accumulate iron deposits unlike in wild-type mice

enlarged spleen ( J:167779 )

• 3 times

increased spleen iron level ( J:167779 )

• 7 times, predominantly in the red pulp

increased spleen red pulp amount ( J:167779 )

liver/biliary system

abnormal Kupffer cell morphology ( J:167779 )

• Kupffer cells accumulate iron deposits unlike in wild-type mice

increased liver iron level ( J:167779 )

• 2 times

growth/size/body

enlarged spleen ( J:167779 )

• 3 times