Phenotypes associated with this allele

• Allele Symbol: Il4^tm2.1Kubo
• Allele Name: targeted mutation 2.1, Masato Kubo
• Allele ID: MGI:4880750
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il4^tm2.1Kubo/Il4^tm2.1Kubo	B6.Cg-Il4^tm2.1Kubo	MGI:4880865

Genotype
MGI:4880865

hm1

• Allelic Composition: Il4^tm2.1Kubo/Il4^tm2.1Kubo
• Genetic Background: B6.Cg-Il4^tm2.1Kubo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired eosinophil recruitment ( J:167446 )

• in bronchoalveolar lavage fluid following acetylcholine treatment of ovalbumin-sensitized and challenged mice

decreased IgE level ( J:167446 )

• in ovalbumin treated mice

decreased IgG1 level ( J:167446 )

• in ovalbumin treated mice

increased IgG2c level ( J:167446 )

• in ovalbumin treated mice

increased interleukin-13 secretion ( J:167446 )

• in T cells stimulated with GATA3 expression

decreased interleukin-4 secretion ( J:167446 )

• in CD4+ T cells

• in NKT cells stimulated by alpha-galactosylceramide

• in Th2 cells

• in T cells stimulated with GATA3 expression

increased interleukin-5 secretion ( J:167446 )

• in T cells stimulated with GATA3 expression

respiratory system

decreased airway responsiveness ( J:167446 )

• following acetylcholine treatment of ovalbumin-sensitized and challenged mice

hematopoietic system

impaired eosinophil recruitment ( J:167446 )

• in bronchoalveolar lavage fluid following acetylcholine treatment of ovalbumin-sensitized and challenged mice

decreased IgE level ( J:167446 )

• in ovalbumin treated mice

decreased IgG1 level ( J:167446 )

• in ovalbumin treated mice

increased IgG2c level ( J:167446 )

• in ovalbumin treated mice