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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp2tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4880891
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp2tm1a(KOMP)Wtsi/Nlrp2tm1a(KOMP)Wtsi Not Specified MGI:6314744


Genotype
MGI:6314744
hm1
Allelic
Composition		 Nlrp2tm1a(KOMP)Wtsi/Nlrp2tm1a(KOMP)Wtsi
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp2tm1a(KOMP)Wtsi mutation (0 available); any Nlrp2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:275254 )
N
• serum levels of anti-Mullerian hormone (AMH), estradiol, progesterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) are similar to controls
abnormal oocyte morphology ( J:275254 )
• irregular oocyte morphology
abnormal ovarian follicle morphology ( J:275254 )
• degenerating follicles in ovaries at 3 weeks of age
abnormal granulosa cell morphology ( J:275254 )
• increased nuclear pyknosis of granulosa cells
decreased secondary ovarian follicle number ( J:275254 )
• significantly fewer secondary follicles at 3 weeks of age
increased atretic ovarian follicle number ( J:275254 )
• atretic follicles at 3 weeks of age
decreased fertilization frequency ( J:275254 )
• decreased fertilization rates

cellular
abnormal oocyte morphology ( J:275254 )
• irregular oocyte morphology
maternal effect ( J:275254 )
• maternal loss of the encoded protein results in decreased fertilization rates, abnormal early cleavage of zygotes and an inability to form blastocysts in vitro

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:275254 )
• degenerating follicles in ovaries at 3 weeks of age
abnormal granulosa cell morphology ( J:275254 )
• increased nuclear pyknosis of granulosa cells
decreased secondary ovarian follicle number ( J:275254 )
• significantly fewer secondary follicles at 3 weeks of age
increased atretic ovarian follicle number ( J:275254 )
• atretic follicles at 3 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory