Phenotypes associated with this allele

• Allele Symbol: Dph6^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4880925
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dph6^tm1a(KOMP)Wtsi/Dph6^tm1a(KOMP)Wtsi	C57BL/6N-Dph6^tm1a(KOMP)Wtsi/Wtsi	MGI:5700870

Genotype
MGI:5700870

hm1

• Allelic Composition: Dph6^{tm1a(KOMP)Wtsi}/Dph6^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dph6^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0702_3_E03

Data Sources

IMPC Data for Dph6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body length ( J:211773 )

♂

IMPC - WTSI

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

IMPC - WTSI

decreased hematocrit ( J:211773 )

IMPC - WTSI

decreased hemoglobin content ( J:211773 )

IMPC - WTSI

increased red blood cell distribution width ( J:211773 )

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased dendritic cell number ( J:211773 )

IMPC - WTSI

increased CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

increased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

increased marginal zone B cell number ( J:211773 )

IMPC - WTSI

increased plasma cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

♂

IMPC - WTSI

increased blood urea nitrogen level ( J:211773 )

♂

IMPC - WTSI

increased circulating magnesium level ( J:211773 )

♂

IMPC - WTSI

immune system

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased dendritic cell number ( J:211773 )

IMPC - WTSI

increased CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

increased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

increased marginal zone B cell number ( J:211773 )

IMPC - WTSI

increased plasma cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

integument

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - WTSI

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - WTSI

skeleton

vertebral transformation ( J:211773 )

♀

IMPC - WTSI