Phenotypes associated with this allele

• Allele Symbol: Gpr35^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4881257
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr35^tm1(KOMP)Vlcg/Gpr35^tm1(KOMP)Vlcg	C57BL/6N-Gpr35^tm1(KOMP)Vlcg/MbpMmucd	MGI:6756406

Genotype
MGI:6756406

hm1

• Allelic Composition: Gpr35^{tm1(KOMP)Vlcg}/Gpr35^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Gpr35^{tm1(KOMP)Vlcg}/MbpMmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to colitis induced morbidity/mortality ( J:306520 )

• in a colitis model, mice pretreated with oral clindamycin/streptomycin and then colonized with enterotoxigenic Bacteroides fragilis (ETBF) show no death after colonization compared to death in 5 of 6 wild-type mice

• in a colitis model, mice pretreated with oral cefoxitin and then colonized with enterotoxigenic Bacteroides fragilis show death in 4% of mutant mice within 7 days of ETBF colonization compared to 46.67% of wild-type mice indicating a decrease in the lethal reaction of mice to ETBF-induced colitis

immune system

decreased susceptibility to induced colitis ( J:306520 )

• mice show less severe colitis after enterotoxigenic Bacteroides fragilis colonization; ETBF-infected mutant mice do not show bleeding, epithelial cell shedding or ulcerations as seen in wild-type mice

decreased susceptibility to colitis induced morbidity/mortality ( J:306520 )

• in a colitis model, mice pretreated with oral clindamycin/streptomycin and then colonized with enterotoxigenic Bacteroides fragilis (ETBF) show no death after colonization compared to death in 5 of 6 wild-type mice

• in a colitis model, mice pretreated with oral cefoxitin and then colonized with enterotoxigenic Bacteroides fragilis show death in 4% of mutant mice within 7 days of ETBF colonization compared to 46.67% of wild-type mice indicating a decrease in the lethal reaction of mice to ETBF-induced colitis

abnormal chemokine level ( J:306520 )

• colitis-induced (via ETBF infection) mice show reduced expression of Cxcl5

abnormal interleukin level ( J:306520 )

• colitis-induced (via ETBF infection) mice show reduced expression of IL-22

digestive/alimentary system

decreased susceptibility to induced colitis ( J:306520 )

• mice show less severe colitis after enterotoxigenic Bacteroides fragilis colonization; ETBF-infected mutant mice do not show bleeding, epithelial cell shedding or ulcerations as seen in wild-type mice

decreased susceptibility to colitis induced morbidity/mortality ( J:306520 )

• in a colitis model, mice pretreated with oral clindamycin/streptomycin and then colonized with enterotoxigenic Bacteroides fragilis (ETBF) show no death after colonization compared to death in 5 of 6 wild-type mice

• in a colitis model, mice pretreated with oral cefoxitin and then colonized with enterotoxigenic Bacteroides fragilis show death in 4% of mutant mice within 7 days of ETBF colonization compared to 46.67% of wild-type mice indicating a decrease in the lethal reaction of mice to ETBF-induced colitis

homeostasis/metabolism

abnormal chemokine level ( J:306520 )

• colitis-induced (via ETBF infection) mice show reduced expression of Cxcl5

abnormal interleukin level ( J:306520 )

• colitis-induced (via ETBF infection) mice show reduced expression of IL-22