Phenotypes associated with this allele

• Allele Symbol: Dagla^tm1.1Kano
• Allele Name: targeted mutation 1.1, Masanobu Kano
• Allele ID: MGI:4881474
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dagla^tm1.1Kano/Dagla^tm1.1Kano	involves: C57BL/6 * C57BL/6N * CBA	MGI:4881711
hm2	Dagla^tm1.1Kano/Dagla^tm1.1Kano	involves: C57BL/6N	MGI:5140394

Genotype
MGI:4881711

hm1

• Allelic Composition: Dagla^tm1.1Kano/Dagla^tm1.1Kano
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:167891 )

• mice exhibit a reduction basal and stimulus-induced 2-arachidonoylglycerol levels in the cerebellum, striatum, and hippocampus compared with wild-type mice

• basal levels of anandamide is decreased in the brain compared to in wild-type mice

abnormal inhibitory postsynaptic currents ( J:167891 )

• mice exhibit defective endocannabinoid-mediated retrograde suppression of synaptic transmission in the cerebellum, hippocampus, and striatum compared with wild-type mice

absent long-term depression ( J:167891 )

• mice lack long term depression of inhibitory synaptic transmission compared with wild-type mice

Genotype
MGI:5140394

hm2

• Allelic Composition: Dagla^tm1.1Kano/Dagla^tm1.1Kano
• Genetic Background: involves: C57BL/6N

nervous system

abnormal excitatory postsynaptic currents ( J:173327 )

• mice lack retrograde suppression of excitation in mossy cell-granule cell synapses unlike in wild-type mice