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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cd4-Zbtb16)1797Aben
transgene insertion 1797, Albert Bendelac
MGI:4881493
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Cd4-Zbtb16)1797Aben/? C57BL/6-Tg(Cd4-Zbtb16)1797Aben MGI:5301112


Genotype
MGI:5301112
tg1
Allelic
Composition
Tg(Cd4-Zbtb16)1797Aben/?
Genetic
Background
C57BL/6-Tg(Cd4-Zbtb16)1797Aben
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-Zbtb16)1797Aben mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD44hiCD62Llo CD4+ T cell subset is increased 5 to 10 times in thymocytes, splenocytes, lung and liver lymphocytes
• IL4 and IFNG producing T cells are increased 4-6 fold following stimulation with anti-CD3 and human IL2 as compared to control
• CD4+ T cells are reduced by greater than 10 fold in the blood and lymph nodes; remaining T cells are CD8+
• normal numbers of CD4+ cells exist in the thymus, spleen, liver and lung

hematopoietic system
• CD44hiCD62Llo CD4+ T cell subset is increased 5 to 10 times in thymocytes, splenocytes, lung and liver lymphocytes
• IL4 and IFNG producing T cells are increased 4-6 fold following stimulation with anti-CD3 and human IL2 as compared to control
• CD4+ T cells are reduced by greater than 10 fold in the blood and lymph nodes; remaining T cells are CD8+
• normal numbers of CD4+ cells exist in the thymus, spleen, liver and lung





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory