Phenotypes associated with this allele

• Allele Symbol: Otop1^ied
• Allele Name: inner ear defect
• Allele ID: MGI:4881519
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otop1^ied/Otop1^ied	involves: C3HeB/FeJ * C57BL/6	MGI:4881521

Genotype
MGI:4881521

hm1

• Allelic Composition: Otop1^ied/Otop1^ied
• Genetic Background: involves: C3HeB/FeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:103243 )

• unsuccessful righting response before 9 days of age

• slow righting response after 15 days of age

impaired coordination ( J:103243 )

• impaired early performance on a rotarod

• improve with trials until equivalent to controls

impaired swimming ( J:103243 )

• unable to swim early

• attempts to swim improve by 2 weeks but still unable to swim

abnormal posture ( J:103243 )

• when held by the tail

head tilt ( J:103243 )

• head tilted to one side

decreased vertical activity ( J:103243 )

• less rearing activity

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:103243 )

N • no major hearing defect

absent otoliths ( J:103243 )

• saccular and utricular maculae lack otoconia

• membrane over hair cells and hair cells of saccular and utricular maculae are normal

• cristae ampullares are normal