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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Dkk3-cre)D9Tfur
transgene insertion D9, Takahisa Furukawa
MGI:4881674
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(Dkk3-cre)D9Tfur/0
Top2btm2Jcw/Top2btm2Jcw 		involves: 129S6/SvEvTac * C3H * C57BL/6 MGI:6382623
cn2
 		Prdm13tm1.1Tfur/Prdm13tm1.1Tfur
Tg(Dkk3-cre)D9Tfur/0 		involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N MGI:5780207


Genotype
MGI:6382623
cn1
Allelic
Composition		 Tg(Dkk3-cre)D9Tfur/0
Top2btm2Jcw/Top2btm2Jcw
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Dkk3-cre)D9Tfur mutation (2 available)
Top2btm2Jcw mutation (1 available); any Top2b mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal photoreceptor outer segment morphology ( J:282250 )
• retina detached from retinal pigment epithelium at age P14 and P21 owing to absence of OS
photoreceptor outer segment degeneration ( J:282250 )
• virtually no OS by age P14
abnormal retina cone cell morphology ( J:282250 )
• m/l-cone outer nuclear layer cells intrude into inner nuclear layer at age P14
abnormal retina cone cell outer segment morphology ( J:282250 )
• shorter neural processes on s-cones at age P0
• no neural processes on s-cones at age P7 and P14
abnormal retina rod cell morphology ( J:282250 )
• outer nuclear layer cells intrude into inner nuclear layer at age P14
abnormal retina rod cell outer segment morphology ( J:282250 )
• elimination or significant reduction of rhodopsin signal at age P7 and P14
retina photoreceptor degeneration ( J:282250 )
• increased apoptosis in outer nuclear layer at age P7, P14 and P21
abnormal retina pigment epithelium morphology ( J:282250 )
• retina detached from RPE at age P14 and P21 owing to absence of outer segment
thin retina outer nuclear layer ( J:282250 )
• at age P7 and P14
abnormal retina outer plexiform layer morphology ( J:282250 )
• absent at age P7, P14 and P21
abnormal retina outer limiting membrane morphology ( J:282250 )
• elimination or significant reduction of rhodopsin signal at age P7 and P14

nervous system
abnormal photoreceptor outer segment morphology ( J:282250 )
• retina detached from retinal pigment epithelium at age P14 and P21 owing to absence of OS
photoreceptor outer segment degeneration ( J:282250 )
• virtually no OS by age P14
abnormal retina cone cell morphology ( J:282250 )
• m/l-cone outer nuclear layer cells intrude into inner nuclear layer at age P14
abnormal retina cone cell outer segment morphology ( J:282250 )
• shorter neural processes on s-cones at age P0
• no neural processes on s-cones at age P7 and P14
abnormal retina rod cell morphology ( J:282250 )
• outer nuclear layer cells intrude into inner nuclear layer at age P14
abnormal retina rod cell outer segment morphology ( J:282250 )
• elimination or significant reduction of rhodopsin signal at age P7 and P14
retina photoreceptor degeneration ( J:282250 )
• increased apoptosis in outer nuclear layer at age P7, P14 and P21

pigmentation
abnormal retina pigment epithelium morphology ( J:282250 )
• retina detached from RPE at age P14 and P21 owing to absence of outer segment




Genotype
MGI:5780207
cn2
Allelic
Composition		 Prdm13tm1.1Tfur/Prdm13tm1.1Tfur
Tg(Dkk3-cre)D9Tfur/0
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm13tm1.1Tfur mutation (1 available); any Prdm13 mutation (46 available)
Tg(Dkk3-cre)D9Tfur mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
decreased amacrine cell number ( J:222242 )
• specific reduction in the number of GABAergic or glycinergic amacrine cells at P14
abnormal retina inner plexiform layer morphology ( J:222242 )
• loss of the S2/S3 border neurite bundle labeled by anti-Calretinin antibodies in the IPL at P14

behavior/neurological
abnormal optokinetic reflex ( J:222242 )
• at 2 months of age, mice exhibit higher responses to visual stimuli in initial optokinetic responses with a broader range of spatial and temporal frequencies than those observed in controls

nervous system
decreased amacrine cell number ( J:222242 )
• specific reduction in the number of GABAergic or glycinergic amacrine cells at P14




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory