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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ackr3tm1Twb
targeted mutation 1, Timothy Behrens
MGI:4881710
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ackr3tm1Twb/Ackr3tm1.1Twb
Tg(Tek-cre)12Flv/0 		involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6 MGI:4881715


Genotype
MGI:4881715
cn1
Allelic
Composition		 Ackr3tm1Twb/Ackr3tm1.1Twb
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr3tm1.1Twb mutation (0 available); any Ackr3 mutation (34 available)
Ackr3tm1Twb mutation (1 available); any Ackr3 mutation (34 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber morphology ( J:167833 )
• cellular disarray and enlarged intercellular spaces at 6 months of age
increased myocardial fiber size ( J:167833 )
• at 6 months of age
cardiac hypertrophy ( J:167833 )
• marked hypertrophy at 6 months of age with much thicker ventricle walls but no change in the size of the ventricular cavity
heart left ventricle hypertrophy ( J:167833 )
• the wall is about 1.4 fold thicker than controls
thick aortic valve ( J:167833 )
• at 6 months of age
• increase in thickness is greater in the aortic valve compared to the pulmonary valve
thick pulmonary valve ( J:167833 )
• at 6 months of age
• increase in thickness is greater in the aortic valve compared to the pulmonary valve
cardiac fibrosis ( J:167833 )
• at 6 months of age

growth/size/body
cardiac hypertrophy ( J:167833 )
• marked hypertrophy at 6 months of age with much thicker ventricle walls but no change in the size of the ventricular cavity
heart left ventricle hypertrophy ( J:167833 )
• the wall is about 1.4 fold thicker than controls

muscle
abnormal myocardial fiber morphology ( J:167833 )
• cellular disarray and enlarged intercellular spaces at 6 months of age
increased myocardial fiber size ( J:167833 )
• at 6 months of age
heart left ventricle hypertrophy ( J:167833 )
• the wall is about 1.4 fold thicker than controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory