Phenotypes associated with this allele

• Allele Symbol: Ackr3^tm1.1Twb
• Allele Name: targeted mutation 1.1, Timothy Behrens
• Allele ID: MGI:4881712
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ackr3^tm1.1Twb/Ackr3^tm1.1Twb	involves: 129S/SvEv * BALB/cJ * C57BL/6	MGI:4881714
cn2	Ackr3^tm1Twb/Ackr3^tm1.1Twb Tg(Tek-cre)12Flv/0	involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6	MGI:4881715

Genotype
MGI:4881714

hm1

• Allelic Composition: Ackr3^tm1.1Twb/Ackr3^tm1.1Twb
• Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:167833 )

• all mice that are born alive die shortly after birth

perinatal lethality, incomplete penetrance ( J:167833 )

• about 1/3 of mice are dead at E18.5

cardiovascular system

abnormal atrioventricular cushion morphology ( J:167833 )

• at E15.5 when outflow tract endocardial cushions in wild-type mice have begun to thin into leaflets, the pulmonary and aortic cushions remain thick indicating defects in valve remodeling

• however, no defects in mitral or tricuspid valves are detected

abnormal heart and great artery attachment ( J:167833 )

• misalignment of the aorta is seen occasionally

overriding aortic valve ( J:167833 )

• in 22% of mice

dilated heart atrium ( J:167833 )

• seen occasionally

perimembraneous ventricular septal defect ( J:167833 )

• seen in 1/3 of mice at E18.5

enlarged heart ( J:167833 )

• slightly enlarged at E18.5

abnormal semilunar valve morphology ( J:167833 )

aortic valve stenosis ( J:167833 )

thick aortic valve ( J:167833 )

• at E18.5

pulmonary valve stenosis ( J:167833 )

thick pulmonary valve ( J:167833 )

• at E18.5

abnormal cardiovascular system physiology ( J:167833 )

• increase in cell proliferation in the semilunar valves at E14,0 and E15.5

hemorrhage ( J:167833 )

• about 1/3 display catastrophic circulatory failure with a blood filled embryonic sac at E18.5

respiratory system

respiratory distress ( J:167833 )

• most mice born alive gasp for breath

homeostasis/metabolism

cyanosis ( J:167833 )

• most mice born alive are cyanotic

growth/size/body

enlarged heart ( J:167833 )

• slightly enlarged at E18.5

Genotype
MGI:4881715

cn2

• Allelic Composition: Ackr3^tm1Twb/Ackr3^tm1.1Twb; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

cardiovascular system

abnormal myocardial fiber morphology ( J:167833 )

• cellular disarray and enlarged intercellular spaces at 6 months of age

increased myocardial fiber size ( J:167833 )

• at 6 months of age

myocardial fiber disarray ( J:167833 )

cardiac hypertrophy ( J:167833 )

• marked hypertrophy at 6 months of age with much thicker ventricle walls but no change in the size of the ventricular cavity

heart left ventricle hypertrophy ( J:167833 )

• the wall is about 1.4 fold thicker than controls

thick aortic valve ( J:167833 )

• at 6 months of age

• increase in thickness is greater in the aortic valve compared to the pulmonary valve

thick pulmonary valve ( J:167833 )

• at 6 months of age

• increase in thickness is greater in the aortic valve compared to the pulmonary valve

cardiac fibrosis ( J:167833 )

• at 6 months of age

growth/size/body

cardiac hypertrophy ( J:167833 )

• marked hypertrophy at 6 months of age with much thicker ventricle walls but no change in the size of the ventricular cavity

heart left ventricle hypertrophy ( J:167833 )

• the wall is about 1.4 fold thicker than controls

muscle

abnormal myocardial fiber morphology ( J:167833 )

• cellular disarray and enlarged intercellular spaces at 6 months of age

increased myocardial fiber size ( J:167833 )

• at 6 months of age

myocardial fiber disarray ( J:167833 )

heart left ventricle hypertrophy ( J:167833 )

• the wall is about 1.4 fold thicker than controls