All Phenotypes Tg(Slc17a6-icre)1Oki MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Slc17a6-icre)1Oki
transgene insertion 1, Ole Kiehn
MGI:4881727

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Epha4^tm1.1Bzh/Epha4^tm1.2Bzh Tg(Slc17a6-icre)1Oki/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:5614433
cn2	Chn1^tm1Ito/Chn1^tm1.1Ito Tg(Slc17a6-icre)1Oki/0	involves: C57BL/6 * C57BL/6NSlc	MGI:5614426

Allelic Composition	Epha4^tm1.1Bzh/Epha4^tm1.2Bzh Tg(Slc17a6-icre)1Oki/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4^tm1.1Bzh mutation (1 available); any Epha4 mutation (67 available)
Epha4^tm1.2Bzh mutation (0 available); any Epha4 mutation (67 available)
Tg(Slc17a6-icre)1Oki mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:209606 )

• quadrupedal hopping gait is dominant at all locomotor frequencies

• occasional alternating gait is seen at lower frequencies

nervous system

abnormal corticospinal tract morphology ( J:209606 )

• increase in axon midline crossing

abnormal spinal cord morphology ( J:209606 )

• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus

abnormal spinal cord dorsal column morphology ( J:209606 )

• wider and the distance from the ventral edge to the surface of the spinal cord is shorter; however, the total area is not different from controls

abnormal nerve fiber response ( J:209606 )

• chemically and electrically stimulated locomotor-like activity in isolated spinal cord preparations induces a synchronous "hopping" locomotor-like activity rather than an alternating locomotor-like activity

Allelic Composition	Chn1^tm1Ito/Chn1^tm1.1Ito Tg(Slc17a6-icre)1Oki/0
Genetic Background	involves: C57BL/6 * C57BL/6NSlc