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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Fev-cre/ERT2)#Yqd
transgene insertion, Yu-Qiang Ding
MGI:4881729
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lmx1btm1Zfc/Lmx1btm1Zfc
Tg(Fev-cre/ERT2)#Yqd/0 		Not Specified MGI:4881775


Genotype
MGI:4881775
cn1
Allelic
Composition		 Lmx1btm1Zfc/Lmx1btm1Zfc
Tg(Fev-cre/ERT2)#Yqd/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1btm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Fev-cre/ERT2)#Yqd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased serotonin level ( J:168054 )
• after tamoxifen induction at P90, brain levels of 5-HT (serotonin) and its metabolite 5-HIAA are reduced to about 60% and 30% of control levels respectively 2-3 weeks after the last dose
• normal: levels of other monoamines in the brain, including norepinephrine and dopamine are unchanged by deletion of Lmx1b in the raphe nuclei




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory