Phenotypes associated with this allele

• Allele Symbol: Phgdh^tm1.2Shfu
• Allele Name: targeted mutation 1.2, Shigeki Furuya
• Allele ID: MGI:4881750
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Phgdh^tm1.2Shfu/Phgdh^tm1.2Shfu Tg(GFAP-cre)25Mes/0	involves: 129P2/OlaHsd * FVB/N	MGI:4881761

Genotype
MGI:4881761

cn1

• Allelic Composition: Phgdh^tm1.2Shfu/Phgdh^tm1.2Shfu; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain weight ( J:167572 )

• at 6 weeks but not at P0

forebrain hypoplasia ( J:167572 )

homeostasis/metabolism

decreased arginine level ( J:167572 )

• arginine levels in the cerebral cortex are decreased compared to in control mice

increased arginine level ( J:167572 )

• arginine levels in the hippocampus are increased compared to in control mice

increased circulating glycine level ( J:167572 )

• serum glycine concentration is subtly increased compared to in control mice

decreased cystathionine level ( J:167572 )

• cystathionine levels in the cerebral cortex and hippocampus are decreased compared to in control mice

decreased glutamic acid level ( J:167572 )

• glutamic acid levels in the hippocampus are decreased compared to in control mice

increased glutamine level ( J:167572 )

• glutamine levels in the hippocampus are increased compared to in control mice

decreased glycine level ( J:167572 )

• free glycine levels in the cerebral cortex are decreased compared to in control mice

decreased phenylalanine level ( J:167572 )

• phenylalanine levels in the cerebral cortex are decreased compared to in control mice

increased phenylalanine level ( J:167572 )

• phenylalanine levels in the hippocampus are increased compared to in control mice

decreased serine level ( J:167572 )

• free L- and D-serine levels in the cerebral cortex and hippocampus are decreased compared to in control mice

• L-serine or D-serine injection results in a greater increase in L-serine and D-serine content than in similarly treated control mice

decreased threonine level ( J:167572 )

• threonine levels in the hippocampus are decreased compared to in control mice

growth/size/body

microcephaly ( J:167572 )

• at P42 but not at P0