About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mylk3tm1Jtst
targeted mutation 1, James Stull
MGI:4881762
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mylk3tm1Jtst/Mylk3tm1Jtst involves: 129S/SvEv * C57BL/6 MGI:4881768
ht2
 		Mylk3tm1Jtst/Mylk3+ involves: 129S/SvEv * C57BL/6 MGI:4881769


Genotype
MGI:4881768
hm1
Allelic
Composition		 Mylk3tm1Jtst/Mylk3tm1Jtst
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylk3tm1Jtst mutation (0 available); any Mylk3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mylk3tm1Jtst/Mylk3+ and Mylk3tm1Jtst/Mylk3tm1Jtst mice exhibit hypertrophic hearts

cardiovascular system
thick interventricular septum ( J:167590 )
• in untreated and isoproterenol treated mice
abnormal heart left ventricle morphology ( J:167590 )
• mice exhibit increased left ventricular end-systolic and end-diastolic dimensions compared with wild-type mice
increased heart left ventricle weight ( J:167590 )
• in untreated and isoproterenol treated mice
cardiac interstitial fibrosis ( J:167590 )
• in the ventricle, but not atria, at 19 to 22 weeks

muscle

growth/size/body
heart left ventricle hypertrophy ( J:167590 )
heart right ventricle hypertrophy ( J:167590 )
increased heart weight ( J:167590 )

cellular
cardiac interstitial fibrosis ( J:167590 )
• in the ventricle, but not atria, at 19 to 22 weeks




Genotype
MGI:4881769
ht2
Allelic
Composition		 Mylk3tm1Jtst/Mylk3+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylk3tm1Jtst mutation (0 available); any Mylk3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mylk3tm1Jtst/Mylk3+ and Mylk3tm1Jtst/Mylk3tm1Jtst mice exhibit hypertrophic hearts

cardiovascular system
cardiac muscle necrosis ( J:167590 )
• in the ventricle but not atria

muscle
cardiac muscle necrosis ( J:167590 )
• in the ventricle but not atria

growth/size/body
increased heart weight ( J:167590 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory