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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mylk3tm1Jtst
targeted mutation 1, James Stull
MGI:4881762
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mylk3tm1Jtst/Mylk3tm1Jtst involves: 129S/SvEv * C57BL/6 MGI:4881768
ht2
 		Mylk3tm1Jtst/Mylk3+ involves: 129S/SvEv * C57BL/6 MGI:4881769


Genotype
MGI:4881768
hm1
Allelic
Composition		 Mylk3tm1Jtst/Mylk3tm1Jtst
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylk3tm1Jtst mutation (0 available); any Mylk3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mylk3tm1Jtst/Mylk3+ and Mylk3tm1Jtst/Mylk3tm1Jtst mice exhibit hypertrophic hearts

cardiovascular system
thick interventricular septum ( J:167590 )
• in untreated and isoproterenol treated mice
abnormal heart left ventricle morphology ( J:167590 )
• mice exhibit increased left ventricular end-systolic and end-diastolic dimensions compared with wild-type mice
increased heart left ventricle weight ( J:167590 )
• in untreated and isoproterenol treated mice
cardiac interstitial fibrosis ( J:167590 )
• in the ventricle, but not atria, at 19 to 22 weeks

muscle

growth/size/body
heart left ventricle hypertrophy ( J:167590 )
heart right ventricle hypertrophy ( J:167590 )
increased heart weight ( J:167590 )

cellular
cardiac interstitial fibrosis ( J:167590 )
• in the ventricle, but not atria, at 19 to 22 weeks




Genotype
MGI:4881769
ht2
Allelic
Composition		 Mylk3tm1Jtst/Mylk3+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylk3tm1Jtst mutation (0 available); any Mylk3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mylk3tm1Jtst/Mylk3+ and Mylk3tm1Jtst/Mylk3tm1Jtst mice exhibit hypertrophic hearts

cardiovascular system
cardiac muscle necrosis ( J:167590 )
• in the ventricle but not atria

muscle
cardiac muscle necrosis ( J:167590 )
• in the ventricle but not atria

growth/size/body
increased heart weight ( J:167590 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory