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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cnot3tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:4881781
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cnot3tm1Pngr/Cnot3tm1Pngr B6.Cg-Cnot3tm1Pngr MGI:4881788
ht2
 		Cnot3tm1Pngr/Cnot3+ B6.Cg-Cnot3tm1Pngr MGI:4881789


Genotype
MGI:4881788
hm1
Allelic
Composition		 Cnot3tm1Pngr/Cnot3tm1Pngr
Genetic
Background		 B6.Cg-Cnot3tm1Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3tm1Pngr mutation (0 available); any Cnot3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality at implantation, complete penetrance ( J:167954 )
• no newborns recovered
• no placental implantations

embryo
abnormal inner cell mass morphology ( J:167954 )
• outgrowth of inner cell mass begins but severe outgrowth defects occur
• trophoblast develops




Genotype
MGI:4881789
ht2
Allelic
Composition		 Cnot3tm1Pngr/Cnot3+
Genetic
Background		 B6.Cg-Cnot3tm1Pngr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3tm1Pngr mutation (0 available); any Cnot3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:167954 )
• morphological changes observed 3 weeks after transverse cardiac constriction are reduced to levels observed in controls when treated with histone deacetylase inhibitors
increased heart weight ( J:167954 )
• heart weight/body weight ratio shows a significantly greater increase than in controls 3 weeks after transverse cardiac constriction
cardiac hypertrophy ( J:167954 )
• observed histologically 3 weeks after transverse cardiac constriction
increased heart left ventricle size ( J:167954 )
• increased left ventricular diameter during systole
cardiac fibrosis ( J:167954 )
• severe 3 weeks after transverse cardiac constriction
abnormal cardiovascular system physiology ( J:167954 )
• heart function improves after treatment with histone deacetylase inhibitors
decreased cardiac muscle contractility ( J:167954 )
• defective contractility on electrical stimulation
decreased heart left ventricle muscle contractility ( J:167954 )
• decreased left ventricular fractional shortening
• also observed in explanted heart Langendorff preparations treated with isoproterenol
decreased left ventricle developed pressure ( J:167954 )
• impaired generation of left ventricular pressure in Langendorff preparations treated with isoproterenol

muscle
decreased cardiac muscle contractility ( J:167954 )
• defective contractility on electrical stimulation
decreased heart left ventricle muscle contractility ( J:167954 )
• decreased left ventricular fractional shortening
• also observed in explanted heart Langendorff preparations treated with isoproterenol

growth/size/body
increased heart weight ( J:167954 )
• heart weight/body weight ratio shows a significantly greater increase than in controls 3 weeks after transverse cardiac constriction
cardiac hypertrophy ( J:167954 )
• observed histologically 3 weeks after transverse cardiac constriction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory