Analysis Tools
nervous system
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• reduced disruption of the blood-brain barrier, as shown by less extravasation of Evans blue (brain edema) 24 h after transient middle cerebral artery occlusion (tMCAO)
• almost no brain edema is seen in the brain regions where infarcts are regularly present
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• significantly lower number of apoptotic neurons 24 h after tMCAO
• normal basal apoptotic turnover rate
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• reduced infarct volume, better overall neurological function (lower Bederson scores) and grip strength in 6- to 8-week-old homozygous mice than in wild-type controls 24 h after tMCAO and permanent middle cerebral artery occlusion (pMCAO) and cortical photothrombosis
• seven of ten mice (70%) survive until day 5 after tMCAO , and five of these are still alive after 1 wk, versus 15 of 15 wild-type mice die by day5
• reduced infarct volume, better overall neurological function (lower Bederson scores) and grip strength in 18- to 20-week-old homozygous mice than in wild-type controls 24 h after tMCAO
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• significantly smaller infarct volumes in 6- to 8-week-old and 18- to 20-week-old male and female homozygous mice than in wild-type sex-matched controls 24 h after subjected to tMCAO
• all infarcts are restricted to the basal ganglia
• neocortex is not affected
• infarct volume did not increase over time
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cellular
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• significantly lower number of apoptotic neurons 24 h after tMCAO
• normal basal apoptotic turnover rate
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• reduced oxidative stress in brains from homozygous mice 24 h after tMCAO and pMACO
• very small ischemia-induced increases in reactive oxygen species (ROS) 24 h after tMCAO and pMCAO
• tissue nitration occurs to a lesser extent in ischemic brains from homozygous mice 24 h after tMCAO
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cardiovascular system
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• no abnormal vascular phenotype
• normal systemic blood pressure, renal and pulmonary functions
• normal cerebral blood flow, cerebral vasculature
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• reduced disruption of the blood-brain barrier, as shown by less extravasation of Evans blue (brain edema) 24 h after transient middle cerebral artery occlusion (tMCAO)
• almost no brain edema is seen in the brain regions where infarcts are regularly present
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homeostasis/metabolism
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• reduced infarct volume, better overall neurological function (lower Bederson scores) and grip strength in 6- to 8-week-old homozygous mice than in wild-type controls 24 h after tMCAO and permanent middle cerebral artery occlusion (pMCAO) and cortical photothrombosis
• seven of ten mice (70%) survive until day 5 after tMCAO , and five of these are still alive after 1 wk, versus 15 of 15 wild-type mice die by day5
• reduced infarct volume, better overall neurological function (lower Bederson scores) and grip strength in 18- to 20-week-old homozygous mice than in wild-type controls 24 h after tMCAO
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• significantly smaller infarct volumes in 6- to 8-week-old and 18- to 20-week-old male and female homozygous mice than in wild-type sex-matched controls 24 h after subjected to tMCAO
• all infarcts are restricted to the basal ganglia
• neocortex is not affected
• infarct volume did not increase over time
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