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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir21atm1.1Eno
targeted mutation 1.1, Eric N Olson
MGI:4881915
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir21atm1.1Eno/Mir21atm1.1Eno involves: C57BL/6 MGI:4881920
cx2
 		Krastm3Tyj/Kras+
Mir21atm1.1Eno/Mir21atm1.1Eno 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 MGI:5317787


Genotype
MGI:4881920
hm1
Allelic
Composition		 Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir21atm1.1Eno mutation (0 available); any Mir21a mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:166911 )
N
• mice exhibit largely normal cardiac morphology and physiology, including response to stress
increased heart weight ( J:166911 )
• angiotensin II-treated mice exhibit a mildly exaggerated increased in heart weight compared with similarly treated wild-type mice

growth/size/body
increased heart weight ( J:166911 )
• angiotensin II-treated mice exhibit a mildly exaggerated increased in heart weight compared with similarly treated wild-type mice




Genotype
MGI:5317787
cx2
Allelic
Composition		 Krastm3Tyj/Kras+
Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm3Tyj mutation (2 available); any Kras mutation (84 available)
Mir21atm1.1Eno mutation (0 available); any Mir21a mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:164198 )
N
• unlike Krastm3Tyj heterozygotes, mice do not develop skin papillomas or lung adenomcarcinomas
increased T cell derived lymphoma incidence ( J:164198 )
• fewer than in Krastm3Tyj heterozygotes
decreased tumor growth/size ( J:164198 )
• mice exhibit decreased total tumor area relative to lung area compared with Krastm3Tyj heterozygotes
• however, tumor cell proliferation is the same as in Krastm3Tyj heterozygotes
increased lung adenoma incidence ( J:164198 )
• mice develop fewer lung adenoma than in Krastm3Tyj heterozygotes
decreased tumor incidence ( J:164198 )
• mice develop fewer thymic lymphoma, lung hyperplasia and lung adenomas than in Krastm3Tyj heterozygotes
decreased lung tumor incidence ( J:164198 )
• fewer lung adenoma than in Krastm3Tyj heterozygotes

respiratory system
increased lung adenoma incidence ( J:164198 )
• mice develop fewer lung adenoma than in Krastm3Tyj heterozygotes
decreased lung tumor incidence ( J:164198 )
• fewer lung adenoma than in Krastm3Tyj heterozygotes
lung epithelium hyperplasia ( J:164198 )
• mice develop fewer lung hyperplasia than in Krastm3Tyj heterozygotes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:164198 )
• fewer than in Krastm3Tyj heterozygotes

hematopoietic system
increased T cell derived lymphoma incidence ( J:164198 )
• fewer than in Krastm3Tyj heterozygotes

immune system
increased T cell derived lymphoma incidence ( J:164198 )
• fewer than in Krastm3Tyj heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory