Phenotypes associated with this allele

• Allele Symbol: Bach2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4882014
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bach2^tm1a(EUCOMM)Wtsi/Bach2^tm1a(EUCOMM)Wtsi	C57BL/6N-Bach2^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5700825

Genotype
MGI:5700825

hm1

• Allelic Composition: Bach2^{tm1a(EUCOMM)Wtsi}/Bach2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Bach2^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0689_1_H02

Data Sources

IMPC Data for Bach2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased immature B cell number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased neutrophil cell number ( J:211773 )

♀

IMPC - WTSI

thrombocytosis ( J:211773 )

♀

IMPC - WTSI

increased CD103-positive CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

decreased CD11b-high dendritic cell number ( J:211773 )

IMPC - WTSI

increased CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

decreased B cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

decreased follicular B cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased NK cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased regulatory T cell number ( J:211773 )

IMPC - WTSI

increased macrophage cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

♀

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♀

IMPC - WTSI

increased circulating iron level ( J:211773 )

IMPC - WTSI

immune system

increased immature B cell number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased neutrophil cell number ( J:211773 )

♀

IMPC - WTSI

increased CD103-positive CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

decreased CD11b-high dendritic cell number ( J:211773 )

IMPC - WTSI

increased CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

decreased B cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

decreased follicular B cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased NK cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased regulatory T cell number ( J:211773 )

IMPC - WTSI

increased macrophage cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

♀

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

♀

IMPC - WTSI

skeleton

abnormal bone structure ( J:211773 )

IMPC - WTSI

decreased bone mineral content ( J:211773 )

♀

IMPC - WTSI

decreased bone mineral density ( J:211773 )

♀

IMPC - WTSI