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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ddx4-cre/ERT2)1Dcas
transgene insertion 1, Diego H Castrillon
MGI:4882088
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Skp1tm1.1Jw/Skp1tm1.2Jw
Tg(Ddx4-cre/ERT2)1Dcas/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:6455746
cn2
 		Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre/ERT2)1Dcas/0 		involves: 129S4/SvJae * FVB/N MGI:4882150
cn3
 		Foxo3tm1Rdp/Foxo3tm1Rdp
Tg(Ddx4-cre/ERT2)1Dcas/0 		involves: 129S6/SvEvTac * FVB/N MGI:4882149


Genotype
MGI:6455746
cn1
Allelic
Composition		 Skp1tm1.1Jw/Skp1tm1.2Jw
Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp1tm1.1Jw mutation (0 available); any Skp1 mutation (18 available)
Skp1tm1.2Jw mutation (0 available); any Skp1 mutation (18 available)
Tg(Ddx4-cre/ERT2)1Dcas mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oocyte degeneration ( J:289957 )
• at 4 months in tamoxifen-treated mice despite being present at 2 months
abnormal chromosomal synapsis ( J:289957 )
• precocious chromosomal desynapsis in the female and male germ cells of tamoxifen-treated mice
abnormal female meiosis ( J:289957 )
• misalignment of chromosomes in the oocytes of tamoxifen treated mice
decreased testis weight ( J:289957 )
• progressive in tamoxifen-treated mice
abnormal spermatogenesis ( J:289957 )
• severe in tamoxifen-treated mice with absent metaphase spermatocytes
azoospermia ( J:289957 )
• absent metaphase spermatocytes and postmeiotic spermatids in tamoxifen-treated mice
arrest of male meiosis ( J:289957 )
• precocious chromosomal desynapsis and pachytene exit leading to absent metaphase spermatocytes in tamoxifen-treated mice
female infertility ( J:289957 )
• in tamoxifen-treated mice

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:289957 )
• impaired meiotic recombination in spermatocytes and oocytes of tamoxifen-treated mice

endocrine/exocrine glands
decreased testis weight ( J:289957 )
• progressive in tamoxifen-treated mice

cellular
oocyte degeneration ( J:289957 )
• at 4 months in tamoxifen-treated mice despite being present at 2 months
azoospermia ( J:289957 )
• absent metaphase spermatocytes and postmeiotic spermatids in tamoxifen-treated mice
abnormal chromosomal synapsis ( J:289957 )
• precocious chromosomal desynapsis in the female and male germ cells of tamoxifen-treated mice
abnormal female meiosis ( J:289957 )
• misalignment of chromosomes in the oocytes of tamoxifen treated mice
arrest of male meiosis ( J:289957 )
• precocious chromosomal desynapsis and pachytene exit leading to absent metaphase spermatocytes in tamoxifen-treated mice
abnormal double-strand DNA break repair ( J:289957 )
• impaired meiotic recombination in spermatocytes and oocytes of tamoxifen-treated mice
maternal effect ( J:289957 )
• in vitro fertilized oocytes fail to sustain preimplantation embryonic development




Genotype
MGI:4882150
cn2
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Ddx4-cre/ERT2)1Dcas mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

reproductive system

growth/size/body
enlarged ovary ( J:138697 )




Genotype
MGI:4882149
cn3
Allelic
Composition		 Foxo3tm1Rdp/Foxo3tm1Rdp
Tg(Ddx4-cre/ERT2)1Dcas/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (51 available)
Tg(Ddx4-cre/ERT2)1Dcas mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal primordial ovarian follicle morphology ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit global follicle activation
enlarged ovary ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit ovarian hypertrophy

reproductive system
abnormal primordial ovarian follicle morphology ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit global follicle activation
enlarged ovary ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit ovarian hypertrophy

growth/size/body
enlarged ovary ( J:138697 )
• mutants treated with tamoxifen to induce cre expression exhibit ovarian hypertrophy




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory