homeostasis/metabolism
N |
• normal 24 and 48 hour fasting levels of glucose, insulin and glucagon
|
• reduced hepatic glucose production during a hyperinsulinemic-euglycemic clamp
|
• decreased insulin secretion response by isolated islets exposed to increased glucose concentrations
|
• elevated insulin after glucose injection
|
• male mice show higher blood glucose in glucose tolerance tests at 4 and 6 months of age
• glucose intolerance in 3 month old male mice
|
• impaired insulin clearance as indicated by a reduced C-peptide to insulin ratio
|
endocrine/exocrine glands
N |
• normal islet architecture
|
• decreased insulin secretion response by isolated islets exposed to increased glucose concentrations
|