Phenotypes associated with this allele

• Allele Symbol: Tg(Wnt7a-EGFP/cre)#Bhr
• Allele Name: transgene insertion, Richard R Behringer
• Allele ID: MGI:4882135
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Wnt7a-EGFP/cre)#Bhr/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:4887234

Genotype
MGI:4887234

cn1

• Allelic Composition: Esr1^tm1.2Mma/Esr1^tm1.2Mma; Tg(Wnt7a-EGFP/cre)#Bhr/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal uterus morphology ( J:167551 )

♀ • in response to 17-beta-estradiol treatment, apoptosis in uterine glandular and luminal epithelium is significantly increased by 3 days post-treatment in mutants compared to treated wild-type

abnormal uterus size ( J:167551 )

♀ • in response to 17-beta-estradiol treatment, uterine weight increases in ovariectomized mutants but not as significantly as in ovariectomized wild-type females at 24 hours and 3 days after treatment

♀ • uterine proliferative response to ICI 182,780 (estrogen antagonist) is fully attenuated in wild-type and mutant females

abnormal uterine receptivity ( J:167551 )

♀ • in mutants, 0 of 6 implantation sites are observed following natural matings or embryo transfer in contrast to wild-type females where 6 of 9 implantation sites are detected