Phenotypes associated with this allele

• Allele Symbol: Kcnj16^tm1Pess
• Allele Name: targeted mutation 1, Mauro Pessia
• Allele ID: MGI:4882146
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnj16^tm1Pess/Kcnj16^tm1Pess	B6.129X1-Kcnj16^tm1Pess	MGI:4887219

Genotype
MGI:4887219

hm1

• Allelic Composition: Kcnj16^tm1Pess/Kcnj16^tm1Pess
• Genetic Background: B6.129X1-Kcnj16^tm1Pess

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nerve fiber response ( J:167533 )

• following ammonium chloride withdrawal, locus coeruleus neurons exhibit reduced increase in firing rate and a 3-fold smaller difference between peak and baseline instantaneous firing frequency, barely detectable initial decrease in firing rate, delay in reaching peak firing frequency, and reduced outward and inward currents compared with wild-type neurons

• in response to 15% CO2, locus coeruleus neurons exhibit a smaller difference between peak and baseline instantaneous firing frequency compared with wild-type neurons

abnormal neuron physiology ( J:167533 )

• following ammonium chloride withdrawal, locus coeruleus neurons exhibit delayed response to cytoplasmic acidification compared with wild-type neurons