Phenotypes associated with this allele

• Allele Symbol: Birc3^tm1Jda
• Allele Name: targeted mutation 1, Jonathan D Ashwell
• Allele ID: MGI:4887220
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Birc3^tm1Jda/Birc3^tm1Jda	B6.Cg-Birc3^tm1Jda	MGI:4887233
hm2	Birc3^tm1Jda/Birc3^tm1Jda	involves: 129 * C57BL/6	MGI:5501260

Genotype
MGI:4887233

hm1

• Allelic Composition: Birc3^tm1Jda/Birc3^tm1Jda
• Genetic Background: B6.Cg-Birc3^tm1Jda

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell apoptosis ( J:166899 )

• in vivo and in vitro, B cell survival is enhanced compared with wild-type cells

• however, addition of BAFF or agonistic anti-CD40 partially rescues normal B cell survival

increased B cell proliferation ( J:166899 )

• in response to anti-mu F(ab')2 or LPS

abnormal lymphocyte cell number ( J:166899 )

• mice exhibit increased lymphocytic infiltrates in the lungs unlike wild-type mice

decreased immature B cell number ( J:166899 )

• the percentage of follicular and immature B cells in the spleen is lower than in wild-type mice

decreased follicular B cell number ( J:166899 )

• the percentage of follicular and immature B cells in the spleen is lower than in wild-type mice

increased B cell number ( J:166899 )

• 5-fold in pooled lymph nodes

• 4-fold in mesenteric lymph nodes

increased marginal zone B cell number ( J:166899 )

• the percentage of marginal zone B cells in the spleen is 3-fold higher than in wild-type mice

increased T cell number ( J:166899 )

• 2-fold in the lymph nodes

increased IgA level ( J:166899 )

• 3-fold

decreased IgG1 level ( J:166899 )

increased IgG3 level ( J:166899 )

increased IgM level ( J:166899 )

abnormal gut-associated lymphoid tissue morphology ( J:166899 )

• enlarged

enlarged mesenteric lymph nodes ( J:166899 )

lymph node hyperplasia ( J:166899 )

• mice exhibit an increased in cell number in peripheral and mesenteric lymph nodes compared with wild-type mice

hematopoietic system

decreased B cell apoptosis ( J:166899 )

• in vivo and in vitro, B cell survival is enhanced compared with wild-type cells

• however, addition of BAFF or agonistic anti-CD40 partially rescues normal B cell survival

increased B cell proliferation ( J:166899 )

• in response to anti-mu F(ab')2 or LPS

abnormal lymphocyte cell number ( J:166899 )

• mice exhibit increased lymphocytic infiltrates in the lungs unlike wild-type mice

decreased immature B cell number ( J:166899 )

• the percentage of follicular and immature B cells in the spleen is lower than in wild-type mice

decreased follicular B cell number ( J:166899 )

• the percentage of follicular and immature B cells in the spleen is lower than in wild-type mice

increased B cell number ( J:166899 )

• 5-fold in pooled lymph nodes

• 4-fold in mesenteric lymph nodes

increased marginal zone B cell number ( J:166899 )

• the percentage of marginal zone B cells in the spleen is 3-fold higher than in wild-type mice

increased T cell number ( J:166899 )

• 2-fold in the lymph nodes

increased IgA level ( J:166899 )

• 3-fold

decreased IgG1 level ( J:166899 )

increased IgG3 level ( J:166899 )

increased IgM level ( J:166899 )

cellular

decreased B cell apoptosis ( J:166899 )

• in vivo and in vitro, B cell survival is enhanced compared with wild-type cells

• however, addition of BAFF or agonistic anti-CD40 partially rescues normal B cell survival

increased B cell proliferation ( J:166899 )

• in response to anti-mu F(ab')2 or LPS

Genotype
MGI:5501260

hm2

• Allelic Composition: Birc3^tm1Jda/Birc3^tm1Jda
• Genetic Background: involves: 129 * C57BL/6

immune system

increased T cell proliferation ( J:199221 )

• in response to anti-CD3 antibody stimulation

• however, proliferation in response to anti-CD3 and anti-CD28 antibody stimulation

increased interferon-gamma secretion ( J:199221 )

• in response to anti-CD3 or anti-CD3 and anti-CD28 antibody stimulation

hematopoietic system

increased T cell proliferation ( J:199221 )

• in response to anti-CD3 antibody stimulation

• however, proliferation in response to anti-CD3 and anti-CD28 antibody stimulation

cellular

increased T cell proliferation ( J:199221 )

• in response to anti-CD3 antibody stimulation

• however, proliferation in response to anti-CD3 and anti-CD28 antibody stimulation