Analysis Tools
homeostasis/metabolism
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• 8-week-old male mutants do not show differences in body weight or daily food intake
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• ad libitum-fed and overnight fasted blood glucose levels of 8-week-old male mutants are significantly reduced relative to controls
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• during glucose tolerance tests, insulin levels are decreased relative to controls, suggesting that decreased glucose levels are not the result of increased insulin secretion
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• 8-week-old males display improved glucose tolerance (after injection of glucose at 2 g/kg body weight), with a significantly reduced rise in blood glucose levels relative to controls
• no alterations in pancreatic beta cells is observed due to ectopic cre expression resulting in Ucp2 deletion in beta cells
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nervous system
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• about 44% of Pmch neurons fire spontaneously at 5 mM glucose, increased from around 30% of control neurons
• membrane potential of Pmch neurons displays enhanced glucose-induced depolarization in response to different glucose concentrations (left-shifted dose-response curve to glucose)
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