Phenotypes associated with this allele

• Allele Symbol: Mbd3^tm2Bh
• Allele Name: targeted mutation 2, Brian Hendrich
• Allele ID: MGI:4887391
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mbd3^tm2Bh/Mbd3^tm2Bh Tg(Vil1-cre)20Syr/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:4887392

Genotype
MGI:4887392

cn1

• Allelic Composition: Mbd3^tm2Bh/Mbd3^tm2Bh; Tg(Vil1-cre)20Syr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal small intestinal crypt cell proliferation ( J:167984 )

• increase in intestinal progenitor cell proliferation in the crypts

increased susceptibility to induced colitis ( J:167984 )

• large increase in proliferating cells compared to controls following DSS treatment

neoplasm

increased incidence of tumors by chemical induction ( J:167984 )

• striking increase in the number of tumors in mice following azoxymethane and DSS treatment

increased tumor growth/size ( J:167984 )

• tumors induced by azoxymethane and DSS treatment are increased in size compared to controls

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:167984 )

• striking increase in the number of tumors in mice following azoxymethane and DSS treatment

immune system

increased susceptibility to induced colitis ( J:167984 )

• large increase in proliferating cells compared to controls following DSS treatment

cellular

abnormal small intestinal crypt cell proliferation ( J:167984 )

• increase in intestinal progenitor cell proliferation in the crypts