All Phenotypes Cdc20<tm1.1Mama> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdc20^tm1.1Mama/Cdc20^tm1.1Mama Pttg1^tm1.1Kna/Pttg1^tm1.1Kna	involves: 129 * C57BL/6 * CD-1 * SJL	MGI:4887576
cn2	Cdc20^tm1.1Mama/Cdc20^tm1.2Mama Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺	involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL	MGI:4887575

Allelic Composition	Cdc20^tm1.1Mama/Cdc20^tm1.1Mama Pttg1^tm1.1Kna/Pttg1^tm1.1Kna
Genetic Background	involves: 129 * C57BL/6 * CD-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc20^tm1.1Mama mutation (1 available); any Cdc20 mutation (30 available)
Pttg1^tm1.1Kna mutation (0 available); any Pttg1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitosis ( J:167609 )

• mouse embryonic fibroblasts treated with a cre-expressing adenovirus exhibit arrest in metaphase unlike control cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:167609 )

• after 8 to 10 days on a tamoxifen diet

• however, survival is increased when older mice (1 year old) are treated with tamoxifen

cellular

abnormal mitosis ( J:167609 )

• tamoxifen-treated mice exhibit widespread metaphase arrest in proliferative areas of the intestine and testis unlike in control mice

• topical treatment results in metaphase figures in the basal layer and in the hair follicle cells in depilated mice compared to in similarly treated control mice

decreased cell proliferation ( J:167609 )

• tamoxifen-treated mice exhibit reduced proliferation in the testis and spleen compared with control mice

neoplasm

decreased tumor growth/size ( J:167609 )

• in a two-stage carcinogenesis protocol, tamoxifen-treated mice exhibit tumor arrest unlike similarly treated control mice

tumor regression ( J:167609 )

• in tamoxifen-treated mice

integument

delayed hair regrowth ( J:167609 )

• following topical application of tamoxifen, depilated mice exhibit impaired hair regeneration compared with similarly treated control mice

abnormal epidermis stratum basale morphology ( J:167609 )

• topical treatment results in metaphase figures in the basal layer compared to in similarly treated control mice

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:167609 )

• tamoxifen-treated mice exhibit loss of intestinal epithelium unlike in control mice

growth/size/body

weight loss ( J:167609 )

• in tamoxifen-treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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