Phenotypes associated with this allele

• Allele Symbol: Cdc20^tm1.1Mama
• Allele Name: targeted mutation 1.1, Marcos Malumbres
• Allele ID: MGI:4887480
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdc20^tm1.1Mama/Cdc20^tm1.1Mama Pttg1^tm1.1Kna/Pttg1^tm1.1Kna	involves: 129 * C57BL/6 * CD-1 * SJL	MGI:4887576
cn2	Cdc20^tm1.1Mama/Cdc20^tm1.2Mama Polr2a^tm1(cre/ERT2)Bbd/Polr2a^+	involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL	MGI:4887575

Genotype
MGI:4887576

cn1

• Allelic Composition: Cdc20^tm1.1Mama/Cdc20^tm1.1Mama; Pttg1^tm1.1Kna/Pttg1^tm1.1Kna
• Genetic Background: involves: 129 * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitosis ( J:167609 )

• mouse embryonic fibroblasts treated with a cre-expressing adenovirus exhibit arrest in metaphase unlike control cells

Genotype
MGI:4887575

cn2

• Allelic Composition: Cdc20^tm1.1Mama/Cdc20^tm1.2Mama; Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺
• Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL

mortality/aging

premature death ( J:167609 )

• after 8 to 10 days on a tamoxifen diet

• however, survival is increased when older mice (1 year old) are treated with tamoxifen

cellular

abnormal mitosis ( J:167609 )

• tamoxifen-treated mice exhibit widespread metaphase arrest in proliferative areas of the intestine and testis unlike in control mice

• topical treatment results in metaphase figures in the basal layer and in the hair follicle cells in depilated mice compared to in similarly treated control mice

decreased cell proliferation ( J:167609 )

• tamoxifen-treated mice exhibit reduced proliferation in the testis and spleen compared with control mice

neoplasm

decreased tumor growth/size ( J:167609 )

• in a two-stage carcinogenesis protocol, tamoxifen-treated mice exhibit tumor arrest unlike similarly treated control mice

tumor regression ( J:167609 )

• in tamoxifen-treated mice

integument

delayed hair regrowth ( J:167609 )

• following topical application of tamoxifen, depilated mice exhibit impaired hair regeneration compared with similarly treated control mice

abnormal epidermis stratum basale morphology ( J:167609 )

• topical treatment results in metaphase figures in the basal layer compared to in similarly treated control mice

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:167609 )

• tamoxifen-treated mice exhibit loss of intestinal epithelium unlike in control mice

growth/size/body

weight loss ( J:167609 )

• in tamoxifen-treated mice