All Phenotypes Hbs1l<tm1a(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hbs1l^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4887599

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hbs1l^{tm1a(KOMP)Wtsi}/Hbs1l^{tm1a(KOMP)Wtsi}	C57BL/6N-Hbs1l^{tm1a(KOMP)Wtsi}/Wtsi	MGI:5700912
hm2	Hbs1l^{tm1a(KOMP)Wtsi}/Hbs1l^{tm1a(KOMP)Wtsi}	C57BL/6NTac-Hbs1l^{tm1a(KOMP)Wtsi}	MGI:6718851

Allelic Composition	Hbs1l^{tm1a(KOMP)Wtsi}/Hbs1l^{tm1a(KOMP)Wtsi}
Genetic Background	C57BL/6N-Hbs1l^{tm1a(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0693_2_A02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbs1l^{tm1a(KOMP)Wtsi} mutation (3 available); any Hbs1l mutation (51 available)

Data Sources

IMPC Data for Hbs1l

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - WTSI

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

abnormal zygomatic bone morphology ( J:272028 )

• depressed zygomatic bones

abnormal facial morphology ( J:272028 )

• mice exhibit abnormal facial structure that is more prevalent in females than males

abnormal tooth morphology ( J:272028 )

• dental asymmetry

malocclusion ( J:272028 )

abnormal nasal bone morphology ( J:272028 )

• 86% of females exhibit depressed nasal bones compared to 43% of males

short nasal bone ( J:272028 )

• 86% of females exhibit shortened nasal bones compared to 14% of males

abnormal snout morphology ( J:211773 )

IMPC - WTSI

asymmetric snout ( J:272028 )

short snout ( J:272028 )

growth/size/body

abnormal facial morphology ( J:272028 )

• mice exhibit abnormal facial structure that is more prevalent in females than males

abnormal tooth morphology ( J:272028 )

• dental asymmetry

malocclusion ( J:272028 )

abnormal nasal bone morphology ( J:272028 )

• 86% of females exhibit depressed nasal bones compared to 43% of males

short nasal bone ( J:272028 )

• 86% of females exhibit shortened nasal bones compared to 14% of males

abnormal snout morphology ( J:211773 )

IMPC - WTSI

asymmetric snout ( J:272028 )

short snout ( J:272028 )

decreased body weight ( J:272028 )

• mice weigh less at various ages

hematopoietic system

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - WTSI

thrombocytosis ( J:211773 )

IMPC - WTSI

increased mean platelet volume ( J:211773 )

IMPC - WTSI

decreased Langerhans cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased monocyte cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - WTSI

increased circulating HDL cholesterol level ( J:211773 )

IMPC - WTSI

increased circulating free fatty acids level ( J:211773 )

IMPC - WTSI

increased circulating iron level ( J:211773 )

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - WTSI

increased circulating total protein level ( J:211773 )

IMPC - WTSI

improved glucose tolerance ( J:211773 )

IMPC - WTSI

immune system

decreased Langerhans cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased monocyte cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

limbs/digits/tail

abnormal tail morphology ( J:211773 )

IMPC - WTSI

pigmentation

abnormal retina pigmentation ( J:272028 )

• atypical retinal pigmentation

reproductive system

male infertility ( J:211773 , J:272028 )

IMPC - WTSI (J:211773)

MGI (J:272028)

respiratory system

abnormal nasal bone morphology ( J:272028 )

• 86% of females exhibit depressed nasal bones compared to 43% of males

short nasal bone ( J:272028 )

• 86% of females exhibit shortened nasal bones compared to 14% of males

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

abnormal tooth morphology ( J:272028 )

• dental asymmetry

malocclusion ( J:272028 )

abnormal nasal bone morphology ( J:272028 )

• 86% of females exhibit depressed nasal bones compared to 43% of males

short nasal bone ( J:272028 )

• 86% of females exhibit shortened nasal bones compared to 14% of males

abnormal zygomatic bone morphology ( J:272028 )

• depressed zygomatic bones

abnormal vertebrae morphology ( J:272028 )

• vertebral defects such as transitional vertebrae and abnormal shape

vertebral transformation ( J:211773 , J:272028 )


	IMPC - WTSI (J:211773)

abnormal bone structure ( J:211773 )

IMPC - WTSI

decreased bone mineral content ( J:211773 )

IMPC - WTSI

vision/eye

cornea opacity ( J:211773 )

IMPC - WTSI

abnormal retina morphology ( J:211773 )

IMPC - WTSI

abnormal retina pigmentation ( J:272028 )

• atypical retinal pigmentation

Allelic Composition	Hbs1l^{tm1a(KOMP)Wtsi}/Hbs1l^{tm1a(KOMP)Wtsi}
Genetic Background	C57BL/6NTac-Hbs1l^{tm1a(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbs1l^{tm1a(KOMP)Wtsi} mutation (3 available); any Hbs1l mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

oligozoospermia ( J:306384 )

• no mice are recovered at E6.5

reproductive system

oligozoospermia ( J:306384 )

• no mice are recovered at E6.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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