All Phenotypes Rag2<tm1.1Flv> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rag2^tm1.1Flv
targeted mutation 1.1, Richard A Flavell
MGI:4887836

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv	involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * BALB/cAnNTac	MGI:5296680
cx2	Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv	involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac	MGI:4887951
cx3	Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Rag2^tm1.1Flv/Rag2^tm1.1Flv	involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac	MGI:4887950
cx4	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Rag2^tm1.1Flv/Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}	involves: 129S4/SvJae * BALB/cAnNTac	MGI:5605181
cx5	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}	involves: 129S4/SvJae * BALB/cAnNTac	MGI:5605192
cx6	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Rag2^tm1.1Flv/Rag2^tm1.1Flv Tg(SIRPA)1Flv/0 Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}	involves: 129S4/SvJae * BALB/cAnNTac	MGI:5605193
cx7	Il2rg^tm1.1Flv/Y Rag2^tm1.1Flv/Rag2^tm1.1Flv	involves: 129S4/SvJae * BALB/cAnNTac	MGI:4887942
cx8	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv Tg(SIRPA)1Flv/0 Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}	involves: 129S4/SvJae * BALB/cAnNTac	MGI:5605194
cx9	Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv	involves: 129S4/SvJae * BALB/cAnNTac	MGI:4887944
cx10	Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}	involves: 129S4/SvJae * BALB/cAnNTac	MGI:4887947

Allelic Composition	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * BALB/cAnNTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1^{tm1.1(CSF1)Flv} mutation (0 available); any Csf1 mutation (48 available)
Il2rg^tm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2^tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177073 )

N	• mice exhibit normal total cell content of the bone marrow, frequencies of myeloid cells in the bone marrow, spleen, and peripheral blood, and the frequencies of macrophages in the bone marrow and spleen

abnormal immune system physiology ( J:177073 )

• mice produce humanized monocytes/macrophages with augmented functional properties (migration, phagocytosis, activation, and responses to LPS) and production of human cytokines

skeleton

skeleton phenotype ( J:177073 )

N	• mice exhibit normal bones

craniofacial

craniofacial phenotype ( J:177073 )

N	• mice exhibit normal teeth

hematopoietic system

hematopoietic system phenotype ( J:177073 )

N	• mice exhibit normal total cell content of the bone marrow, frequencies of myeloid cells in the bone marrow, spleen, and peripheral blood, and the frequencies of macrophages in the bone marrow and spleen

Allelic Composition	Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv
Genetic Background	involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2/Il3^{tm1.1(CSF2,IL3)Flv} mutation (2 available); any Csf2 mutation (35 available)
Il2rg^tm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2^tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to transplant ( J:168302 )

• mice exhibit improved engraftment with CD34+ hematopoietic cells with improved human myeloid cell reconstitution in the lung compared with wild-type mice

Allelic Composition	Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Rag2^tm1.1Flv/Rag2^tm1.1Flv
Genetic Background	involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2/Il3^{tm1.1(CSF2,IL3)Flv} mutation (1 available); any Il3 mutation (31 available)
Il2rg^tm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2^tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to transplant ( J:168302 )

• mice exhibit improved engraftment with CD34+ hematopoietic cells with improved human myeloid cell reconstitution in the lung compared with wild-type mice

Allelic Composition	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Rag2^tm1.1Flv/Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}
Genetic Background	involves: 129S4/SvJae * BALB/cAnNTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1^{tm1.1(CSF1)Flv} mutation (0 available); any Csf1 mutation (48 available)
Csf2/Il3^{tm1.1(CSF2,IL3)Flv} mutation (1 available); any Il3 mutation (31 available)
Il2rg^tm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2^tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
Thpo^{tm1.1(TPO)Flv} mutation (1 available); any Thpo mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to transplant ( J:207289 )

• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/Sz J controls

• peripheral blood is mostly composed of human monocytes

• bone marrow is composed of human monocytes and neutrophils

• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls

• numbers of human NK cells found in blood and liver are higher in engrafted mutant as compared to controls, however, numbers are not as high as in mice that also carry Tg(SIRPA)1Flv

• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls

• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls

Allelic Composition	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}
Genetic Background	involves: 129S4/SvJae * BALB/cAnNTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1^{tm1.1(CSF1)Flv} mutation (0 available); any Csf1 mutation (48 available)
Csf2/Il3^{tm1.1(CSF2,IL3)Flv} mutation (2 available); any Csf2 mutation (35 available)
Il2rg^tm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2^tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
Thpo^{tm1.1(TPO)Flv} mutation (1 available); any Thpo mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to transplant ( J:207289 )

• peripheral blood is mostly composed of human monocytes

• bone marrow is composed of human monocytes and neutrophils

• numbers of myeloid cells in non lymphoid tissues (lung, liver, colon) are incerased by 10 fold that of controls

• numbers of human NK cells found in blood and liver are higher in engrafted mutant as compared to controls, however, numbers are not as high as in mice that also carry Tg(SIRPA)1Flv

• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls

• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls

Allelic Composition	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Rag2^tm1.1Flv/Rag2^tm1.1Flv Tg(SIRPA)1Flv/0 Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}
Genetic Background	involves: 129S4/SvJae * BALB/cAnNTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1^{tm1.1(CSF1)Flv} mutation (0 available); any Csf1 mutation (48 available)
Csf2/Il3^{tm1.1(CSF2,IL3)Flv} mutation (1 available); any Il3 mutation (31 available)
Il2rg^tm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2^tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
Tg(SIRPA)1Flv mutation (1 available)
Thpo^{tm1.1(TPO)Flv} mutation (1 available); any Thpo mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to transplant ( J:207289 )

• peripheral blood is mostly composed of human monocytes

• bone marrow is composed of human monocytes and neutrophils

• monocyte subpopulations are similar to populations found in human peripheral blood and bone marrow

• transplanted mice develop human eosinophils, basophils and dendritic cells in bone marrow and blood

• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls

• numbers of human NK cells found in blood and liver are 10x higher in engrafted mutant as compared to controls

• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls

• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls

Allelic Composition	Il2rg^tm1.1Flv/Y Rag2^tm1.1Flv/Rag2^tm1.1Flv
Genetic Background	involves: 129S4/SvJae * BALB/cAnNTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rg^tm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2^tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:168303 )

• mice engrafted with human fetal liver hematopoietic and progenitor cells support S. Typhi replication and persistent infection

abnormal response to transplant ( J:168303 )

• mice exhibit engraftment with human fetal liver hematopoietic and progenitor cells to reconstitution a functional human immune system

Allelic Composition	Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv Tg(SIRPA)1Flv/0 Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}
Genetic Background	involves: 129S4/SvJae * BALB/cAnNTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1^{tm1.1(CSF1)Flv} mutation (0 available); any Csf1 mutation (48 available)
Csf2/Il3^{tm1.1(CSF2,IL3)Flv} mutation (2 available); any Csf2 mutation (35 available)
Il2rg^tm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2^tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
Tg(SIRPA)1Flv mutation (1 available)
Thpo^{tm1.1(TPO)Flv} mutation (1 available); any Thpo mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to transplant ( J:207289 )

• peripheral blood is mostly composed of human monocytes

• bone marrow is composed of human monocytes and neutrophils

• monocyte subpopulations are similar to populations found in human peripheral blood and bone marrow

• transplanted mice develop human eosinophils, basophils and dendritic cells in bone marrow and blood

• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls

• numbers of human NK cells found in blood and liver are 10x higher in engrafted mutant as compared to controls

• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls

• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls

Allelic Composition	Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv
Genetic Background	involves: 129S4/SvJae * BALB/cAnNTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:168303 )

• mice engrafted with human fetal liver hematopoietic and progenitor cells support S. Typhi replication and persistent infection

abnormal response to transplant ( J:168303 )

• mice exhibit engraftment with human fetal liver hematopoietic and progenitor cells to reconstitution a functional human immune system

Allelic Composition	Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv}
Genetic Background	involves: 129S4/SvJae * BALB/cAnNTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to transplant ( J:168301 )

• mice exhibit increased levels of human engraftment in the bone marrow with improved multilineage differentiation of hematopoietic cells and an increased ratio of myelomonocytic versus lymphoid lineages compared with wild-type mice

hematopoietic system

thrombocytopenia ( J:168301 )

• in engrafted and non-engrafted mice

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