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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Csf2/Il3tm1.1(CSF2,IL3)Flv
targeted mutation 1.1, Richard A Flavell
MGI:4887881
Summary 3 genotypes


Genotype
MGI:4887950
cx1
Allelic
Composition		 Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Genetic
Background		 involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (1 available); any Il3 mutation (31 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:168302 )
• mice exhibit improved engraftment with CD34+ hematopoietic cells with improved human myeloid cell reconstitution in the lung compared with wild-type mice




Genotype
MGI:5605181
cx2
Allelic
Composition		 Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background		 involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (48 available)
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (1 available); any Il3 mutation (31 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:207289 )
• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz J controls
• peripheral blood is mostly composed of human monocytes
• bone marrow is composed of human monocytes and neutrophils
• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls
• numbers of human NK cells found in blood and liver are higher in engrafted mutant as compared to controls, however, numbers are not as high as in mice that also carry Tg(SIRPA)1Flv
• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls
• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls




Genotype
MGI:5605193
cx3
Allelic
Composition		 Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv
Il2rgtm1.1Flv/Il2rgtm1.1Flv
Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv
Rag2tm1.1Flv/Rag2tm1.1Flv
Tg(SIRPA)1Flv/0
Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic
Background		 involves: 129S4/SvJae * BALB/cAnNTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf1tm1.1(CSF1)Flv mutation (0 available); any Csf1 mutation (48 available)
Csf2/Il3tm1.1(CSF2,IL3)Flv mutation (1 available); any Il3 mutation (31 available)
Il2rgtm1.1Flv mutation (6 available); any Il2rg mutation (179 available)
Rag2tm1.1Flv mutation (6 available); any Rag2 mutation (119 available)
Tg(SIRPA)1Flv mutation (1 available)
Thpotm1.1(TPO)Flv mutation (1 available); any Thpo mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:207289 )
• mice transplanted with human fetal liver-derived hematopoietic CD34+ cells exhibit increased numbers of human myeloid cells (CD33+) in blood and bone marrow as compared to NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz J controls
• peripheral blood is mostly composed of human monocytes
• bone marrow is composed of human monocytes and neutrophils
• monocyte subpopulations are similar to populations found in human peripheral blood and bone marrow
• transplanted mice develop human eosinophils, basophils and dendritic cells in bone marrow and blood
• numbers of human myeloid cells in non lymphoid tissues (lung, liver, colon) are increased by 10 fold that of controls
• numbers of human NK cells found in blood and liver are 10x higher in engrafted mutant as compared to controls
• engrafted tumors exhibit increased numbers of human myelomonocytic cells and are larger in volume as compared to controls
• following LPS injection or Listeria infection, levels of human TNFA, IL6 and IFNB are increased as compared to controls




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11/12/2024
MGI 6.24 		The Jackson Laboratory